Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins - Wikidata - wikimedia - TriplyDB

Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins

Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins

http://www.wikidata.org/entity/Q24622025

about

DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down Syndrome Regulation of eukaryotic gene expression by the untranslated gene regions and other non-coding elements The association of foot structure and footwear fit with disability in children and adolescents with Down syndrome MicroRNAs as potential biomarkers for noninvasive detection of fetal trisomy 21.miRNA-155 upregulation and complement factor H deficits in Down's syndrome.MicroRNA-125b-2 overexpression represses ectodermal differentiation of mouse embryonic stem cells.Molecular and cellular alterations in Down syndrome: toward the identification of targets for therapeutics Prenatal Evaluation of MicroRNA Expressions in Pregnancies with Down Syndrome.Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.Integrated microRNA and protein expression analysis reveals novel microRNA regulation of targets in fetal down syndrome.Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome.Extracellular chromosome 21-derived microRNAs in euploid & aneuploid pregnancies.Functions of noncoding RNAs in neural development and neurological diseases.MiR-125 in normal and malignant hematopoiesis.The spectrum of pulmonary malformation in trisomy-21 patient. A review with emphasis on the molecular-genetic basis.Human diseases caused by germline and somatic abnormalities in microRNA and microRNA-related genes.12p microRNA expression in fibroblast cell lines from probands with Pallister-Killian syndrome.Screening of potential biomarkers for prenatal diagnosis of trisomy 21.Overexpression of Chromosome 21 miRNAs May Affect Mitochondrial Function in the Hearts of Down Syndrome Fetuses.Sorting receptors at Down's syndrome synapses.Expression patterns of the chromosome 21 MicroRNA cluster (miR-99a, miR-125b and let-7c) in chorioamniotic membranes.Differentially expressed miRNAs in trisomy 21 placentas.Down syndrome and microRNAs.Diagnostic Role of MicroRNA Expression Profile in the Prenatal Amniotic Fluid Samples of Pregnant Women with Down Syndrome.Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome.

P2860

Q26745413-220B0F3D-339B-4FB9-9EE1-540A06E4371A Q34271240-5A0CDABE-E29D-45D6-A15B-B748E7F0877E Q35125683-EB7BE099-E38C-4F19-BE3A-7E14A71385A5 Q35599553-2B8B8CC4-F978-45D8-B5E0-0528CFAFE1E4 Q35690949-39CBA48A-C674-4F2B-8ADF-ED9F18CFB474 Q35849946-2D038FF1-C38D-4B0E-826B-0B9CA90537B9 Q36111546-BDB33CF0-6C4C-421F-8D2A-1206AB190638 Q36773506-EA4A92FD-C563-4B43-9829-D6D4765C80D7 Q37045414-01CADF96-FD61-4562-9847-ADCBA6BE6CBD Q37403230-8921BD7A-4F6C-4786-BDB8-FD6E96301B05 Q37548268-4AA733D9-C1AA-467C-A741-F7C2D117FC60 Q37690852-B79511C9-81F3-4CE6-A8D7-23BDDB07B15A Q37942074-D67F3A81-33EF-4683-985C-7A2FF71FCFF6 Q37997926-7B8B581B-36BA-4CC9-8143-84A743809087 Q38002132-E5F6E2DE-1685-4049-BC40-AB6D2E3C66B2 Q38170524-135C01D7-CA48-49E0-92C8-7C7619DEF467 Q38979398-FE3291F8-C3DA-47AD-9CC2-AA71F1539593 Q39064384-C785F8B9-8F01-4B90-AD99-ACA231397CF2 Q43379339-35BAC399-26E7-4A79-BA13-B956305AA70E Q44492886-8F6D48CA-99CA-4449-96E5-E167D7F3D97B Q45049566-A40BF742-8DB1-4A5C-A1E3-64649F7C46F4 Q48193333-AABE96CE-CA34-4C32-8761-B5758E434525 Q49233869-7E91F774-72C1-483B-8EF9-D8C93F7D9CC2 Q50014921-C605604B-B2AB-45E5-A9D6-3FFB4E1F5F3E Q55456404-ACB09E61-808E-46B2-A3F7-D13DDD5E9257

P2860

Trisomy-21 gene dosage over-expression of miRNAs results in the haploinsufficiency of specific target proteins

http://www.wikidata.org/entity/Q24622025

description

2010 nî lūn-bûn

@nan

2010 թուականին հրատարակուած գիտական յօդուած

@hyw

2010 թվականին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@ast

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@en

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@nl

type

label

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@ast

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@en

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@nl

prefLabel

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@ast

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@en

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@nl

P1433

Q24622025-8C35EF2E-F1F4-4F59-824C-D668B0E0BE10

P1476

Q24622025-805C3C82-B01F-4D5B-8AEB-CE4B095D1B71

P2093

Q24622025-27488ACD-CFBE-4A12-B4F8-4ABEFDCD4DF3

Q24622025-A1CDF967-C285-409E-BBFB-9F4804F3062B

Q24622025-DD681B44-16B4-4983-968E-FD13B5D2CB79

P2860

Q24622025-00C0D1C4-EBB2-48BC-BBC3-ED843A097CD8

Q24622025-039A94CF-3F17-4B78-AA0B-621C389AD1D8

Q24622025-06269113-F3FC-45FD-A7DB-378664C72F96

Q24622025-06FB6735-6496-4D80-B18C-B43D7DC6378B

Q24622025-08DA921B-C394-4E00-9248-C3C8347E7733

Q24622025-0A5AB8CC-2CB4-4CF4-A117-14D2CD2D7B0C

Q24622025-0ADEC7A9-7983-44C7-A63A-9086A6754AE1

Q24622025-0B9BD9C9-7C9D-45F9-9A47-8F99B39C1D3D

Q24622025-0E69712C-1294-4546-A985-05FD964490FB

Q24622025-0FF57B43-B823-4F57-AAC5-E0A1D8AFFCBD

P304

Q24622025-3070474D-E7EF-4F84-B53B-D546B545C16C

P31

Q24622025-3FD6C6DB-188B-4E34-A918-B1A939C55837

P3181

Q24622025-BC32E1F0-C00B-4A81-BA89-85BF0CF6C458

P356

Q24622025-059A4949-7FC2-42C1-95F9-76B62EA4583C

P407

Q24622025-53ADD019-5561-422F-9ED9-246A46B2C04E

P433

Q24622025-8BC501F1-D466-4FA3-8354-EB13C9FEE60E

P478

Q24622025-69A57E16-CA61-42A8-B212-3EAFAC66FEDF

P577

Q24622025-9F4009EE-8B6D-4165-BA6D-0EFEADF490B4

P5875

Q24622025-33E7DEC3-9D59-454B-AA84-9AF3A2DFB555

P698

Q24622025-6E856EAE-9D07-4736-B97B-13A2D83E7E07

P921

Q24622025-5ADDB825-80F2-4AC5-9510-79CDD9169991

Q24622025-69612F70-EB19-4610-8994-EFD2BC259CF9

P932

Q24622025-B6C97121-B011-4AF6-A001-8843CF99433D

P3181

P356

P1433

P1476

Trisomy-21 gene dosage over-ex ...... cy of specific target proteins

@en

P2093

Mickey M Martin

http://www.w3.org/2001/XMLSchema#string

Sarah E Sansom

http://www.w3.org/2001/XMLSchema#string

Terry S Elton

http://www.w3.org/2001/XMLSchema#string

P2860

Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells.

Accumulation of miR-155 and BIC RNA in human B cell lymphomas

MicroRNAs: target recognition and regulatory functions

Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers

The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microRNA-155 binding

MeCP2, a key contributor to neurological disease, activates and represses transcription

Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder

miRBase: tools for microRNA genomics

Most mammalian mRNAs are conserved targets of microRNAs

Human microRNA-155 on chromosome 21 differentially interacts with its polymorphic target in the AGTR1 3' untranslated region: a mechanism for functional single-nucleotide polymorphisms related to phenotypes

P304

540-7

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P3181

1064878

http://www.w3.org/2001/XMLSchema#string

P356

10.4161/RNA.7.5.12685

http://www.w3.org/2001/XMLSchema#string

P407

P433

5

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P577

2010-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

47809333

http://www.w3.org/2001/XMLSchema#string

P698

21081842

http://www.w3.org/2001/XMLSchema#string

P921

haploinsufficiency

P932

3073250

http://www.w3.org/2001/XMLSchema#string