Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction - Wikidata - wikimedia - TriplyDB

Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction

Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction

http://www.wikidata.org/entity/Q24622074

about

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis NRP1 function and targeting in neurovascular development and eye disease Control of cellular motility by neuropilin-mediated physical interactions Crystal Structure of the Neuropilin-1 MAM Domain: Completing the Neuropilin-1 Ectodomain Picture VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation Anti-tumor activity of a novel HS-mimetic-vascular endothelial growth factor binding small molecule Structural studies of neuropilin-2 reveal a zinc ion binding site remote from the vascular endothelial growth factor binding pocket Microplate-based screening for small molecule inhibitors of neuropilin-2/vascular endothelial growth factor-C interactions Vasculogenic mimicry of HT1080 tumour cells in vivo: critical role of HIF-1α-neuropilin-1 axis.Production of soluble human vascular endothelial growth factor VEGF-A165-heparin binding domain in Escherichia coli.Effect of C-terminal sequence on competitive semaphorin binding to neuropilin-1 Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC Targeting angiogenesis in esophagogastric adenocarcinoma.Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth.Neuropilin 1 expression correlates with the Radio-resistance of human non-small-cell lung cancer cells.Antitumor activity of Triolimus: a novel multidrug-loaded micelle containing Paclitaxel, Rapamycin, and 17-AAG.Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression.Nordihydroguaiaretic acid impairs prostate cancer cell migration and tumor metastasis by suppressing neuropilin 1.Application of NMR methods to the study of the interaction of natural products with biomolecular receptors.How neuropilin-1 regulates receptor tyrosine kinase signalling: the knowns and known unknowns.Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity.siRNA delivery: from lipids to cell-penetrating peptides and their mimics.The chemistry and biology of organic guanidine derivatives.Function of members of the neuropilin family as essential pleiotropic cell surface receptors.Neuropilins: a new target for cancer therapy.Neuropilin 1: function and therapeutic potential in cancer.Neuropilin regulation of angiogenesis, arteriogenesis, and vascular permeability The emerging role of class-3 semaphorins and their neuropilin receptors in oncology.Neuropilin-1 as Therapeutic Target for Malignant Melanoma.NRP1 transport of cancer therapeutics mediated by tumor-penetrating peptides.VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors.A modified thymosin alpha 1 inhibits the growth of breast cancer both in vitro and in vivo: suppressment of cell proliferation, inducible cell apoptosis and enhancement of targeted anticancer effects.Exogenous recombinant dimeric neuropilin-1 is sufficient to drive angiogenesis.Quantification and cell-to-cell variation of vascular endothelial growth factor receptors.Genetic status of KRAS modulates the role of Neuropilin-1 in tumorigenesis.Mechanistic basis for the potent anti-angiogenic activity of semaphorin 3F Tuftsin signals through its receptor neuropilin-1 via the transforming growth factor beta pathway.Tumor-penetrating Peptide Conjugated and Doxorubicin Loaded T1-T2 Dual Mode MRI Contrast Agents Nanoparticles for Tumor Theranostics.VEGF as a potential target in lung cancer.

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P2860

Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction

http://www.wikidata.org/entity/Q24622074

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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Journal of Medicinal Chemistry

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Small molecule inhibitors of t ...... factor A (VEGF-A) interaction

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P2093

Ashley Jarvis

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Basil Hartzoulakis

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Birger Herzog

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Charles K Allerston

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Chris Chapman

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David L Selwood

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Haiyan Jia

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Ian Zachary

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James Nally

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Katie Ellard

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P2860

Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth

Crystal structure of the human neuropilin-1 b1 domain

Structural basis for ligand and heparin binding to neuropilin B domains

Coot: model-building tools for molecular graphics

The CCPN data model for NMR spectroscopy: development of a software pipeline

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

The finer things in X-ray diffraction data collection

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

Phasercrystallographic software

Refinement of macromolecular structures by the maximum-likelihood method

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2215-26

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3099717

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10.1021/JM901755G

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5

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53

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Paul C. Driscoll

Acely Garza-Garcia

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2010-03-11T00:00:00Z

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41426080

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20151671

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2841442

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