Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
about
Alzheimer mechanisms and therapeutic strategiesSynaptic vesicle trafficking and Parkinson's diseaseAmyloid beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS developmentNaturally secreted amyloid-beta increases mammalian target of rapamycin (mTOR) activity via a PRAS40-mediated mechanismInhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.An epigenetic blockade of cognitive functions in the neurodegenerating brainLevetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse modelsProtein phosphatases and Alzheimer's diseaseAmyloidosis in Retinal Neurodegenerative DiseasesTHE ROLE OF CYSTEINE PROTEASE IN ALZHEIMER DISEASEApolipoprotein E: from cardiovascular disease to neurodegenerative disordersEmerging Link between Alzheimer's Disease and Homeostatic Synaptic PlasticityPrecocious Alterations of Brain Oscillatory Activity in Alzheimer's Disease: A Window of Opportunity for Early Diagnosis and TreatmentConnectivity of Pathology: The Olfactory System as a Model for Network-Driven Mechanisms of Alzheimer's Disease Pathogenesis"Is dopamine involved in Alzheimer's disease?"The involvement of microRNAs in neurodegenerative diseasesApolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer diseaseConnecting the dots between tau dysfunction and neurodegenerationNeuroinflammation in Alzheimer's diseaseAlzheimer's disease, amyloid peptide and synaptic dysfunctionTau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's diseaseA γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APPStriatal-enriched protein tyrosine phosphatase in Alzheimer's disease.The dendritic hypothesis for Alzheimer's disease pathophysiology.Alzheimer Disease: Crosstalk between the Canonical Wnt/Beta-Catenin Pathway and PPARs Alpha and GammaThe Glymphatic System: A Beginner's GuideStem cell therapy for Alzheimer's disease and related disorders: current status and future perspectivesElevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer's disease mouse model.The role of mTOR signaling in Alzheimer diseaseAβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic lossHsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairmentNonhuman primate models of Alzheimer-like cerebral proteopathyDysfunction of Wnt signaling and synaptic disassembly in neurodegenerative diseases.A Network Diffusion Model of Disease Progression in DementiaDendritic spine pathology in neuropsychiatric disordersHierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex.Modification of a small β-barrel protein, to give pseudo-amyloid structures, inhibits amyloid β-peptide aggregation.Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols.Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology
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P2860
Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
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2010年学术文章
@wuu
2010年学术文章
@zh-cn
2010年学术文章
@zh-hans
2010年学术文章
@zh-my
2010年学术文章
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2010年學術文章
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name
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@ast
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@en
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@nl
type
label
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@ast
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@en
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@nl
prefLabel
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@ast
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@en
Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@nl
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Amyloid-beta-induced neuronal ...... ynapses toward neural networks
@en
P2093
Jorge J Palop
Lennart Mucke
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10.1038/NN.2583
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P577
2010-07-01T00:00:00Z
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P6179
1014775684