SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells - Wikidata - wikimedia - TriplyDB

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

http://www.wikidata.org/entity/Q24626021

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Sirtuins and Cancer: Role in the Epithelial-Mesenchymal Transition Intracellular Mono-ADP-Ribosylation in Signaling and Disease The controversial world of sirtuins Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming Metabolism, longevity and epigenetics SIRTain regulators of premature senescence and accelerated aging From sirtuin biology to human diseases: an update Redox control of senescence and age-related disease Rejuvenating sirtuins: the rise of a new family of cancer drug targets Sirtuins: guardians of mammalian healthspan.The Identification of a SIRT6 Activator from Brown Algae Fucus distichus The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis The promoter methylation status and mRNA expression levels of CTCF and SIRT6 in sporadic breast cancer Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.SIRT6 promotes COX-2 expression and acts as an oncogene in skin cancer.SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner Expression and function of SIRT6 in muscle invasive urothelial carcinoma of the bladder JNK Phosphorylates SIRT6 to Stimulate DNA Double-Strand Break Repair in Response to Oxidative Stress by Recruiting PARP1 to DNA Breaks.Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.Sorting out functions of sirtuins in cancer Sirtuin 6 promotes transforming growth factor-β1/H2O2/HOCl-mediated enhancement of hepatocellular carcinoma cell tumorigenicity by suppressing cellular senescence.Global histone deacetylase enzymatic activity is an independent prognostic marker associated with a shorter overall survival in chronic lymphocytic leukemia patients Sirtuins Function as the Modulators in Aging-related Diseases in Common or Respectively Recent progress in genetics of aging, senescence and longevity: focusing on cancer-related genes.Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling.Decreased levels of proapoptotic factors and increased key regulators of mitochondrial biogenesis constitute new potential beneficial features of long-lived growth hormone receptor gene-disrupted mice.Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6 The emerging and diverse roles of sirtuins in cancer: a clinical perspective.Roles of NAD (+) , PARP-1, and Sirtuins in Cell Death, Ischemic Brain Injury, and Synchrotron Radiation X-Ray-Induced Tissue Injury.Upregulation of SIRT6 predicts poor prognosis and promotes metastasis of non-small cell lung cancer via the ERK1/2/MMP9 pathway.SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity.Geroncogenesis: metabolic changes during aging as a driver of tumorigenesis.Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair.Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging.Sirtuins, metabolism, and cancer.Sirtuin activators and inhibitors.SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis.Sirtuin 6 plays an oncogenic role and induces cell autophagy in esophageal cancer cells.Characterization of TP53 and PI3K signaling pathways as molecular targets in gynecologic malignancies.Putative tumor suppression function of SIRT6 in endometrial cancer.

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SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

http://www.wikidata.org/entity/Q24626021

description

2011 nî lūn-bûn

@nan

2011 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի սեպտեմբերին հրատարակված գիտական հոդված

@hy

2011年の論文

@ja

2011年論文

@yue

2011年論文

@zh-hant

2011年論文

@zh-hk

2011年論文

@zh-mo

2011年論文

@zh-tw

2011年论文

@wuu

name

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@ast

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@en

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@nl

type

label

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@ast

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@en

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@nl

prefLabel

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@ast

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@en

SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@nl

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SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

@en

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Andrei Seluanov

http://www.w3.org/2001/XMLSchema#string

Michael Van Meter

http://www.w3.org/2001/XMLSchema#string

Zhiyong Mao

http://www.w3.org/2001/XMLSchema#string

P2860

Hallmarks of Cancer: The Next Generation

Human SIRT6 promotes DNA end resection through CtIP deacetylation

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

Understanding the Warburg effect: the metabolic requirements of cell proliferation

CBP/p300-mediated acetylation of histone H3 on lysine 56

Aberrant rel/nfkb genes and activity in human cancer

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

From polyploidy to aneuploidy, genome instability and cancer

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

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3153-8

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scholarly article

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930928

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10.4161/CC.10.18.17435

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18

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10

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2011-09-15T00:00:00Z

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51626688

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21900744

http://www.w3.org/2001/XMLSchema#string

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apoptotic process

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3218623

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