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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

http://www.wikidata.org/entity/Q24627125

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Protein phosphatase 2A dysfunction in Alzheimer's disease Phosphatases of α-synuclein, LRRK2, and tau: important players in the phosphorylation-dependent pathology of Parkinsonism Therapeutic benefits of a component of coffee in a rat model of Alzheimer's disease.Neuroprotective and anti-inflammatory properties of a coffee component in the MPTP model of Parkinson's disease Protein phosphatases and Alzheimer's disease Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease Ceramides in Alzheimer's Disease: Key Mediators of Neuronal Apoptosis Induced by Oxidative Stress and Aβ Accumulation Translation system engineering in Escherichia coli enhances non-canonical amino acid incorporation into proteins.Folic Acid Reduces Tau Phosphorylation by Regulating PP2A Methylation in Streptozotocin-Induced Diabetic Mice.Phosphorylated protein phosphatase 2A determines poor outcome in patients with metastatic colorectal cancer.Neuroprotective Functions for the Histone Deacetylase SIRT6 SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitination.Network Analysis of a Comprehensive Knowledge Repository Reveals a Dual Role for Ceramide in Alzheimer's Disease.PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice.Ionic immune suppression within the tumour microenvironment limits T cell effector function.Therapeutic strategies for tau mediated neurodegeneration.Vitamin E in aging, dementia, and Alzheimer's disease.Invited review: Drug development for tauopathies.Behind the curtain of tauopathy: a show of multiple players orchestrating tau toxicity.All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase.Tau-directed approaches for the treatment of Alzheimer's disease: focus on leuco-methylthioninium.Ligands for Ser/Thr phosphoprotein phosphatases: a patent review (2005-2015).New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.The B55α regulatory subunit of protein phosphatase 2A mediates fibroblast growth factor-induced p107 dephosphorylation and growth arrest in chondrocytes.Novel "Elements" of Immune Suppression within the Tumor Microenvironment.An experimental rat model of sporadic Alzheimer's disease and rescue of cognitive impairment with a neurotrophic peptide.The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats.Vitamin E family: Role in the pathogenesis and treatment of Alzheimer's disease.CME-1, a novel polysaccharide, suppresses iNOS expression in lipopolysaccharide-stimulated macrophages through ceramide-initiated protein phosphatase 2A activation.PP2A deactivation is a common event in oral cancer and reactivation by FTY720 shows promising therapeutic potential.Tau-based therapeutics for Alzheimer's disease: active and passive immunotherapy.The Role of Fluoxetine in Activating Wnt/β-Catenin Signaling and Repressing β-Amyloid Production in an Alzheimer Mouse Model.Cornel Iridoid Glycoside Inhibits Tau Hyperphosphorylation via Regulating Cross-Talk Between GSK-3β and PP2A Signaling.A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer's Disease Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

http://www.wikidata.org/entity/Q24627125

description

2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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type

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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prefLabel

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

@ast

Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

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Future Medicinal Chemistry

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Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease

@en

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Jeffry B Stock

http://www.w3.org/2001/XMLSchema#string

Michael Voronkov

http://www.w3.org/2001/XMLSchema#string

Steven P Braithwaite

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P2860

Structural and biochemical insights into the regulation of protein phosphatase 2A by small t antigen of SV40

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

Hyperphosphorylation induces self-assembly of tau into tangles of paired helical filaments/straight filaments

A specific protein carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain

Structural mechanism of demethylation and inactivation of protein phosphatase 2A

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

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821-33

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scholarly article

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487446

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10.4155/FMC.11.47

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51195042

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21644827

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Alzheimer's disease

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3292348

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