Identification and characterization of a melanin-concentrating hormone receptor
about
Elucidation of signaling properties of vasopressin receptor-related receptor 1 by using the chimeric receptor approachBrain regulation of energy balance and body weight.Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolismCitric acid cycle intermediates as ligands for orphan G-protein-coupled receptorsThe role of melanin-concentrating hormone and its receptors in energy homeostasisPeriplakin interferes with G protein activation by the melanin-concentrating hormone receptor-1 by binding to the proximal segment of the receptor C-terminal tail.High-throughput screening of novel antagonists on melanin-concentrating hormone receptor-1.Meta-analysis of melanin-concentrating hormone signaling-deficient mice on behavioral and metabolic phenotypesRegulation of pigmentation in zebrafish melanophores.Melanin-concentrating hormone functions in the nervous system: food intake and stress.Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity modelsMelanin-concentrating hormone receptor mutations and human obesity: functional analysis.Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2.Melanin-concentrating hormone-1 receptor modulates neuroendocrine, behavioral, and corticolimbic neurochemical stress responses in mice.To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance.Melanin-concentrating hormone and its receptors: state of the art.Obesity therapy: altering the energy intake-and-expenditure balance sheet.Melanin-concentrating hormone neuron system: the Wide Web that controls the feeding.Therapeutic potential of melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity.Human Th2 cells selectively express the orexigenic peptide, pro-melanin-concentrating hormone.Lateral hypothalamic orexin and melanin-concentrating hormone neurons provide direct input to gonadotropin-releasing hormone neurons in the human.The brain-adipose axis: a review of involvement of molecules.Discovery and pharmacological effects of a novel GPR142 antagonist.[¹⁸F]FE@SNAP-A new PET tracer for the melanin concentrating hormone receptor 1 (MCHR1): microfluidic and vessel-based approachesMelanin-concentrating hormone as a mediator of intestinal inflammation.Preparation and First Preclinical Evaluation of [(18)F]FE@SNAP: A Potential PET Tracer for the Melanin-Concentrating Hormone Receptor-1 (MCHR1)Control of ventricular ciliary beating by the melanin concentrating hormone-expressing neurons of the lateral hypothalamus: a functional imaging survey.Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction.Expression of melanin-concentrating hormone receptor 2 protects against diet-induced obesity in male mice.Cellular models for the study of the pharmacology and signaling of melanin-concentrating hormone receptors.Appetite control and obesity.Discovery and development of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.Regulated Control of Melanin-Concentrating Hormone Receptor 1 through Posttranslational Modifications.The MCH(1) receptor, an anti-obesity target, is allosterically inhibited by 8-methylquinoline derivatives possessing subnanomolar binding and long residence times.Different structural requirements for melanin-concentrating hormone (MCH) interacting with rat MCH-R1 (SLC-1) and mouse B16 cell MCH-R.Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs.In vivo evaluation of radiotracers targeting the melanin-concentrating hormone receptor 1: [11C]SNAP-7941 and [18F]FE@SNAP reveal specific uptake in the ventricular system.Radiosynthesis of [11C]SNAP-7941--the first PET-tracer for the melanin concentrating hormone receptor 1 (MCHR1).Mutation of Phe318 within the NPxxY(x)(5,6)F motif in melanin-concentrating hormone receptor 1 results in an efficient signaling activity.Melanin-concentrating hormone activates signaling pathways in 3T3-L1 adipocytes.
P2860
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P2860
Identification and characterization of a melanin-concentrating hormone receptor
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Identification and characterization of a melanin-concentrating hormone receptor
@ast
Identification and characterization of a melanin-concentrating hormone receptor
@en
Identification and characterization of a melanin-concentrating hormone receptor
@nl
type
label
Identification and characterization of a melanin-concentrating hormone receptor
@ast
Identification and characterization of a melanin-concentrating hormone receptor
@en
Identification and characterization of a melanin-concentrating hormone receptor
@nl
prefLabel
Identification and characterization of a melanin-concentrating hormone receptor
@ast
Identification and characterization of a melanin-concentrating hormone receptor
@en
Identification and characterization of a melanin-concentrating hormone receptor
@nl
P2093
P2860
P356
P1476
Identification and characterization of a melanin-concentrating hormone receptor
@en
P2093
P2860
P304
P356
10.1073/PNAS.131200698
P407
P577
2001-06-19T00:00:00Z