Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site
about
Gephyrin, the enigmatic organizer at GABAergic synapsesFunctional regulation of GABAA receptors in nervous system pathologiesDiffusion dynamics of synaptic molecules during inhibitory postsynaptic plasticityA conformational switch in collybistin determines the differentiation of inhibitory postsynapsesDesign and synthesis of high-affinity dimeric inhibitors targeting the interactions between gephyrin and inhibitory neurotransmitter receptorsMolecular basis of the alternative recruitment of GABA(A) versus glycine receptors through gephyrinStructural characterization of gephyrin by AFM and SAXS reveals a mixture of compact and extended statesSimultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathyPin1-dependent signalling negatively affects GABAergic transmission by modulating neuroligin2/gephyrin interactionGenetic deficiency of GABA differentially regulates respiratory and non-respiratory motor neuron development.Gephyrin Cleavage in In Vitro Brain Ischemia Decreases GABAA Receptor Clustering and Contributes to Neuronal Death.A pivotal role of GSK-3 in synaptic plasticity.γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting.Disrupting the clustering of GABAA receptor α2 subunits in the frontal cortex leads to reduced γ-power and cognitive deficits.Molecular and functional heterogeneity of GABAergic synapses.Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses.Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors.Role of GABAA R trafficking in the plasticity of inhibitory synapses.Regulation of GABAergic synapse development by postsynaptic membrane proteins.Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbersGABAA receptor α and γ subunits shape synaptic currents via different mechanisms.Phosphorylation of gephyrin in hippocampal neurons by cyclin-dependent kinase CDK5 at Ser-270 is dependent on collybistin.Direct binding of GABAA receptor β2 and β3 subunits to gephyrin.Gephyrin-binding peptides visualize postsynaptic sites and modulate neurotransmission.GARLH Family Proteins Stabilize GABAA Receptors at Synapses.Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses.Assembly and maintenance of GABAergic and Glycinergic circuits in the mammalian nervous system.Structure-Function Relationships of Glycine and GABA Receptors and Their Interplay With the Scaffolding Protein GephyrinDevelopmental seizures and mortality result from reducing GABA receptor α2-subunit interaction with collybistin
P2860
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P2860
Gephyrin-mediated γ-aminobutyric acid type A and glycine receptor clustering relies on a common binding site
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2011 nî lūn-bûn
@nan
2011 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
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2011年论文
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Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@ast
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@en
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@nl
type
label
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@ast
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@en
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@nl
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Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@ast
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@en
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@nl
P2093
P2860
P356
P1476
Gephyrin-mediated γ-aminobutyr ...... elies on a common binding site
@en
P2093
Hans-Michael Maric
Jayanta Mukherjee
Stephen J Moss
Verena Tretter
P2860
P304
P356
10.1074/JBC.M111.303412
P407
P577
2011-12-09T00:00:00Z