Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency
about
Structural mechanism for sterol sensing and transport by OSBP-related proteins.Structural basis for glycosphingolipid transfer specificityVitamin E, antioxidant and nothing moreIntracellular transport of fat-soluble vitamins A and EThoughts on Sec14-like nanoreactors and phosphoinositide signalingThe α-tocopherol transfer protein is essential for vertebrate embryogenesisOpen and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand bindingBothnia dystrophy is caused by domino-like rearrangements in cellular retinaldehyde-binding protein mutant R234WImpaired α-TTP-PIPs interaction underlies familial vitamin E deficiencyA novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicityEngineering tocopherol selectivity in α-TTP: a combined in vitro/in silico studyConformational dynamics of the major yeast phosphatidylinositol transfer protein sec14p: insight into the mechanisms of phospholipid exchange and diseases of sec14p-like protein deficiencies.Regulation of phosphoinositide levels by the phospholipid transfer protein Sec14p controls Cdc42p/p21-activated kinase-mediated cell cycle progression at cytokinesisThe Sec14 superfamily and mechanisms for crosstalk between lipid metabolism and lipid signalingAlpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice.Alpha-tocopherol transfer protein disruption confers resistance to malarial infection in mice.Molecular dynamics guided design of tocoflexol: a new radioprotectant tocotrienol with enhanced bioavailabilitySynthesis and characterization of BODIPY-alpha-tocopherol: a fluorescent form of vitamin E.Cross-species analyses identify the BNIP-2 and Cdc42GAP homology (BCH) domain as a distinct functional subclass of the CRAL_TRIO/Sec14 superfamilyHepatic α-tocopherol transfer protein: ligand-induced protection from proteasomal degradation.The contribution of surface residues to membrane binding and ligand transfer by the α-tocopherol transfer protein (α-TTP)Unleashing the untold and misunderstood observations on vitamin E.Crystallization and preliminary X-ray diffraction analysis of Sfh3, a member of the Sec14 protein superfamily.Mechanisms of recognition and binding of α-TTP to the plasma membrane by multi-scale molecular dynamics simulations.The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane traffickingPhosphatidylinositol transfer proteins and functional specification of lipid signaling pools.Does gamma-tocopherol play a role in the primary prevention of heart disease and cancer? A review.Phosphatidylinositol transfer proteins and cellular nanoreactors for lipid signaling.Aldehydes and disturbance of carbohydrate metabolism: some consequences and possible approaches to its normalization.Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol.So many options but one choice: the human body prefers alpha-tocopherol. A matter of stereochemistryPhosphatidylinositol transfer proteins: negotiating the regulatory interface between lipid metabolism and lipid signaling in diverse cellular processes.Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality.Functional plasticity of the BNIP-2 and Cdc42GAP Homology (BCH) domain in cell signaling and cell dynamics.A history of vitamin E.Self-assembled α-Tocopherol Transfer Protein Nanoparticles Promote Vitamin E Delivery Across an Endothelial Barrier.Utility of a fluorescent vitamin E analogue as a probe for tocopherol transfer protein activityIdentification of CRALBP ligand interactions by photoaffinity labeling, hydrogen/deuterium exchange, and structural modeling.Copy Number Variation and Expression Analysis Reveals a Nonorthologous Pinta Gene Family Member Involved in Butterfly Vision.Bioavailability of alpha-tocopherol stereoisomers in rats depends on dietary doses of all-rac- or RRR-alpha-tocopheryl acetate.
P2860
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P2860
Crystal structure of human alpha-tocopherol transfer protein bound to its ligand: implications for ataxia with vitamin E deficiency
description
2003 nî lūn-bûn
@nan
2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Crystal structure of human alp ...... axia with vitamin E deficiency
@ast
Crystal structure of human alp ...... axia with vitamin E deficiency
@en
Crystal structure of human alp ...... axia with vitamin E deficiency
@nl
type
label
Crystal structure of human alp ...... axia with vitamin E deficiency
@ast
Crystal structure of human alp ...... axia with vitamin E deficiency
@en
Crystal structure of human alp ...... axia with vitamin E deficiency
@nl
altLabel
Crystal structure of human -t ...... axia with vitamin E deficiency
@en
prefLabel
Crystal structure of human alp ...... axia with vitamin E deficiency
@ast
Crystal structure of human alp ...... axia with vitamin E deficiency
@en
Crystal structure of human alp ...... axia with vitamin E deficiency
@nl
P2093
P2860
P921
P356
P1476
Crystal structure of human alp ...... axia with vitamin E deficiency
@en
P2093
K Christopher Min
Rhett A Kovall
Wayne A Hendrickson
P2860
P304
P356
10.1073/PNAS.2136684100
P407
P577
2003-12-09T00:00:00Z