Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator
about
Allosteric modulator Desformylflustrabromine relieves the inhibition of α2β2 and α4β2 nicotinic acetylcholine receptors by β-amyloid(1-42) peptideDeconstruction of the α4β2 nicotinic acetylcholine receptor positive allosteric modulator desformylflustrabromineOrthosteric and Allosteric Ligands of Nicotinic Acetylcholine Receptors for Smoking CessationTargeting α4β2 nicotinic acetylcholine receptors in central nervous system disorders: perspectives on positive allosteric modulation as a therapeutic approach.Pharmacological characterization of the allosteric modulator desformylflustrabromine and its interaction with alpha4beta2 neuronal nicotinic acetylcholine receptor orthosteric ligands.Structural answers and persistent questions about how nicotinic receptors work.Allosteric modulators of the α4β2 subtype of neuronal nicotinic acetylcholine receptors.Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations.Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor.Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 SubunitActivation of the α7 nicotinic ACh receptor induces anxiogenic effects in rats which is blocked by a 5-HT₁a receptor antagonist.Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-Selective Positive Allosteric Modulator.Allosteric modulation of alpha4beta2 nicotinic acetylcholine receptors by HEPESPositive allosteric modulation of α4β2 nicotinic acetylcholine receptors as a new approach to smoking reduction: evidence from a rat model of nicotine self-administration.Effects of neuronal nicotinic acetylcholine receptor allosteric modulators in animal behavior studies.Recent progress in neuroactive marine natural products.Doubly prenylated tryptamines: cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A.Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors.Effects of soluble β-amyloid on the release of neurotransmitters from rat brain synaptosomes.Effects of nicotine in combination with drugs described as positive allosteric nicotinic acetylcholine receptor modulators in vitro: discriminative stimulus and hypothermic effects in mice.Reversal of Nicotine Withdrawal Signs through Positive Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors in Male Mice.Discriminative-stimulus effects of NS9283, a nicotinic α4β2* positive allosteric modulator, in nicotine-discriminating rats.Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet.LY2087101 and dFBr share transmembrane binding sites in the (α4)3(β2)2 Nicotinic Acetylcholine Receptor.
P2860
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P2860
Synthesis of desformylflustrabromine and its evaluation as an alpha4beta2 and alpha7 nACh receptor modulator
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@ast
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@en
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@nl
type
label
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@ast
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@en
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@nl
prefLabel
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@ast
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@en
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@nl
P2093
P2860
P1476
Synthesis of desformylflustrab ...... alpha7 nACh receptor modulator
@en
P2093
Anshul Padnya
Brian W Edmonds
Jin-Sung Kim
Maegan Weltzin
Marvin K Schulte
Richard A Glennon
P2860
P304
P356
10.1016/J.BMCL.2007.06.047
P407
P577
2007-09-01T00:00:00Z