The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
about
The schizophrenia susceptibility factor dysbindin and its associated complex sort cargoes from cell bodies to the synapseNucleocytoplasmic shuttling of dysbindin-1, a schizophrenia-related protein, regulates synapsin I expressionSchizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in DrosophilaMolecular mechanisms driving homeostatic plasticity of neurotransmitter releaseSynaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia.Homeostatic plasticity at the Drosophila neuromuscular junctionOn the Teneurin track: a new synaptic organization molecule emergesClustered coding variants in the glutamate receptor complexes of individuals with schizophrenia and bipolar disorderCoordinating different homeostatic processesModeling psychiatric disorders at the cellular and network levelsDysbindin-1 modulates prefrontal cortical activity and schizophrenia-like behaviors via dopamine/D2 pathways.Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.Mutations in the BLOC-1 subunits dysbindin and muted generate divergent and dosage-dependent phenotypes.Synaptic dysbindin-1 reductions in schizophrenia occur in an isoform-specific manner indicating their subsynaptic location.Reduced survival of motor neuron (SMN) protein in motor neuronal progenitors functions cell autonomously to cause spinal muscular atrophy in model mice expressing the human centromeric (SMN2) genePresynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement.Linking neurodevelopmental and synaptic theories of mental illness through DISC1The 2nd Schizophrenia International Research Society Conference, 10-14 April 2010, Florence, Italy: summaries of oral sessions.Lack of change in markers of presynaptic terminal abundance alongside subtle reductions in markers of presynaptic terminal plasticity in prefrontal cortex of schizophrenia patients.Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Brain rhythms connect impaired inhibition to altered cognition in schizophrenia.Dysbindin and Schizophrenia: it's dopamine and glutamate all over again.Rab3-GAP controls the progression of synaptic homeostasis at a late stage of vesicle release.MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons.Gene dosage in the dysbindin schizophrenia susceptibility network differentially affect synaptic function and plasticitySingle-cell optogenetic excitation drives homeostatic synaptic depression.Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilienceTranssynaptic control of presynaptic Ca²⁺ influx achieves homeostatic potentiation of neurotransmitter release.A single-cross, RNA interference-based genetic tool for examining the long-term maintenance of homeostatic plasticityS6 kinase localizes to the presynaptic active zone and functions with PDK1 to control synapse developmentThe N-ethylmaleimide-sensitive factor and dysbindin interact to modulate synaptic plasticity.GABAB receptor deficiency causes failure of neuronal homeostasis in hippocampal networksQuantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction.Deletions in chromosome 6p22.3-p24.3, including ATXN1, are associated with developmental delay and autism spectrum disordersA large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenanceRegulation of synaptic activity by snapin-mediated endolysosomal transport and sorting.Spontaneous transmitter release is critical for the induction of long-term and intermediate-term facilitation in AplysiaNeuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.
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P2860
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
description
2009 nî lūn-bûn
@nan
2009 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@ast
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@en
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@nl
type
label
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@ast
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@en
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@nl
prefLabel
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@ast
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@en
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@nl
P2860
P3181
P356
P1433
P1476
The schizophrenia susceptibility gene dysbindin controls synaptic homeostasis
@en
P2093
Dion K Dickman
Graeme W Davis
P2860
P304
P3181
P356
10.1126/SCIENCE.1179685
P407
P577
2009-11-20T00:00:00Z