Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

Item
http://www.wikidata.org/entity/Q24634116
Discovery of a series of 2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)acetamides as novel molecular switches that modulate modes of K(v)7.2 (KCNQ2) channel pharmacology: identification of (S)-2-phenyl-N-(2-(pyrrolidin-1-yl)phenyl)butanamide (ML252) as a poHigh throughput screening technologies for ion channelsDifferential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673.Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370Functional and molecular evidence for Kv7 channel subtypes in human detrusor from patients with and without bladder outflow obstruction.Investigation of miscellaneous hERG inhibition in large diverse compound collection using automated patch-clamp assay.Atomic basis for therapeutic activation of neuronal potassium channels.Kv7.5 Potassium Channel Subunits Are the Primary Targets for PKA-Dependent Enhancement of Vascular Smooth Muscle Kv7 Currents.Oxidation potentials of N-modified derivatives of the analgesic flupirtine linked to potassium KV 7 channel opening activity but not hepatocyte toxicity.Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Characterizing human stem cell-derived sensory neurons at the single-cell level reveals their ion channel expression and utility in pain research.KV7 Channel Pharmacological Activation by the Novel Activator ML213: Role for Heteromeric KV7.4/KV7.5 Channels in Guinea Pig Detrusor Smooth Muscle Function.Perivascular adipose tissue and the dynamic regulation of Kv 7 and Kir channels: Implications for resistant hypertension.Sequence determinants of subtype-specific actions of KCNQ channel openers.KV channels and the regulation of vascular smooth muscle tone.Thallium Flux Assay for Measuring the Activity of Monovalent Cation Channels and Transporters.Pharmacophore modeling, 3D-QSAR, and in silico ADME prediction of N-pyridyl and pyrimidine benzamides as potent antiepileptic agents.
P2860

Discovery, Synthesis, and Structure–Activity Relationship of a Series of N -Aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener

Item
http://www.wikidata.org/entity/Q24634116
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@ast
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@en
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@nl
type
label
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@ast
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@en
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@nl
prefLabel
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@ast
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@en
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932
P356
P1433
P1476
Discovery, Synthesis, and Stru ...... KCNQ4 Potassium Channel Opener
@en
P2093
P2860
P304
P31
P356
P433
P478
P50
P577
P5875
P698
P921
P932