Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting
about
Activators of G protein signaling in the kidneyImmunomodulatory effects mediated by serotoninGα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years laterGpr126 functions in Schwann cells to control differentiation and myelination via G-protein activationInhibition of G-protein βγ signaling enhances T cell receptor-stimulated interleukin 2 transcription in CD4+ T helper cellsCell-Autonomous Gβ Signaling Defines Neuron-Specific Steady State Serotonin Synthesis in Caenorhabditis elegansThe Gβγ-Src signaling pathway regulates TNF-induced necroptosis via control of necrosome translocationFBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex.Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responsesInvestigational beta-2 adrenergic agonists for the treatment of chronic obstructive pulmonary disease.Subcellular optogenetic inhibition of G proteins generates signaling gradients and cell migration.Stimulation of α1a adrenergic receptors induces cellular proliferation or antiproliferative hypertrophy dependent solely on agonist concentrationA chemical biology approach demonstrates G protein βγ subunits are sufficient to mediate directional neutrophil chemotaxis.Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complexThe G protein-coupled receptor P2Y14 influences insulin release and smooth muscle function in mice.G-protein βγ subunit dimers modulate kidney repair after ischemia-reperfusion injury in rats.New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signalingEvidence for α-helices in the large intracellular domain mediating modulation of the α1-glycine receptor by ethanol and Gβγ.Drug-induced sensitization of adenylyl cyclase: assay streamlining and miniaturization for small molecule and siRNA screening applications.Bias analyses of preclinical and clinical D2 dopamine ligands: studies with immediate and complex signaling pathwaysNeuropeptide Y and somatostatin inhibit insulin secretion through different mechanisms.Inhibition of G-Protein βγ Signaling Decreases Levels of Messenger RNAs Encoding Proinflammatory Cytokines in T Cell Receptor-Stimulated CD4(+) T Helper Cells.Medium-chain fatty acids modulate myocardial function via a cardiac odorant receptor.β2-adrenergic receptor control of endosomal PTH receptor signaling via Gβγ.Adrenaline rush: the role of adrenergic receptors in stimulant-induced behaviorsMolecular targeting of Gα and Gβγ subunits: a potential approach for cancer therapeutics.Heart failure-specific changes in protein kinase signalling.Update on ultra-long-acting β agonists in chronic obstructive pulmonary disease.Biased agonism: An emerging paradigm in GPCR drug discovery.Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation.G protein βγ subunits inhibit TRPM3 ion channels in sensory neurons.Gallein, a Gβγ subunit signalling inhibitor, inhibits metastatic spread of tumour cells expressing OR51E2 and exposed to its odorant ligand.Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels.Gβγ subunit activation promotes dopamine efflux through the dopamine transporter.Polycystin 1 loss of function is directly linked to an imbalance in G-protein signaling in the kidney.Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor.
P2860
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P2860
Understanding molecular recognition by G protein βγ subunits on the path to pharmacological targeting
description
2011 nî lūn-bûn
@nan
2011 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
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2011年學術文章
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name
Understanding molecular recogn ...... h to pharmacological targeting
@ast
Understanding molecular recogn ...... h to pharmacological targeting
@en
Understanding molecular recogn ...... h to pharmacological targeting
@nl
type
label
Understanding molecular recogn ...... h to pharmacological targeting
@ast
Understanding molecular recogn ...... h to pharmacological targeting
@en
Understanding molecular recogn ...... h to pharmacological targeting
@nl
prefLabel
Understanding molecular recogn ...... h to pharmacological targeting
@ast
Understanding molecular recogn ...... h to pharmacological targeting
@en
Understanding molecular recogn ...... h to pharmacological targeting
@nl
P2860
P356
P1476
Understanding molecular recogn ...... h to pharmacological targeting
@en
P2093
Alan V Smrcka
P2860
P356
10.1124/MOL.111.073072
P407
P577
2011-10-01T00:00:00Z