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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

http://www.wikidata.org/entity/Q24643464

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Analyzing effects of naturally occurring missense mutations Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins Molecular mechanisms of disease-causing missense mutations Chronic Beryllium Disease: revealing the role of beryllium ion and small peptides binding to HLA-DP2 Cancer missense mutations alter binding properties of proteins and their interaction networks Combining structural modeling with ensemble machine learning to accurately predict protein fold stability and binding affinity effects upon mutation Rational design of small-molecule stabilizers of spermine synthase dimer by virtual screening and free energy-based approach In silico and in vitro investigations of the mutability of disease-causing missense mutation sites in spermine synthase Domain-mediated protein interaction prediction: From genome to network.Modulating protein-protein interactions with small molecules: the importance of binding hotspots.An X-linked channelopathy with cardiomegaly due to a CLIC2 mutation enhancing ryanodine receptor channel activity.siRNA knockdown of ribosomal protein gene RPL19 abrogates the aggressive phenotype of human prostate cancer.Determining effects of non-synonymous SNPs on protein-protein interactions using supervised and semi-supervised learning.Computational analysis of missense mutations causing Snyder-Robinson syndrome Oncogenic potential is related to activating effect of cancer single and double somatic mutations in receptor tyrosine kinases Enhancing human spermine synthase activity by engineered mutations On the role of electrostatics in protein-protein interactions.Predicting the Impact of Missense Mutations on Protein-Protein Binding Affinity.On the energy components governing molecular recognition in the framework of continuum approaches Predicting folding free energy changes upon single point mutations Structural assessment of the effects of amino acid substitutions on protein stability and protein protein interaction.Convert your favorite protein modeling program into a mutation predictor: "MODICT"SAAMBE: Webserver to Predict the Charge of Binding Free Energy Caused by Amino Acids Mutations.A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.Docking-based modeling of protein-protein interfaces for extensive structural and functional characterization of missense mutations.Exploring Protein-Protein Interactions as Drug Targets for Anti-cancer Therapy with In Silico Workflows.Integration of structural dynamics and molecular evolution via protein interaction networks: a new era in genomic medicine.Annotating Mutational Effects on Proteins and Protein Interactions: Designing Novel and Revisiting Existing Protocols.Purification of Ovine Respiratory Complex I Results in a Highly Active and Stable Preparation.Computational investigation of cancer-associated molecular mechanism in Aurora A (S155R) mutation.On human disease-causing amino acid variants: statistical study of sequence and structural patterns.Revealing the Effects of Missense Mutations Causing Snyder-Robinson Syndrome on the Stability and Dimerization of Spermine Synthase.The Contribution of Missense Mutations in Core and Rim Residues of Protein-Protein Interfaces to Human Disease.Screening of nucleotide variations in genomic sequences encoding charged protein regions in the human genome.Decoding disease-causing mechanisms of missense mutations from supramolecular structures.Prediction of phenotypes of missense mutations in human proteins from biological assemblies.A rational free energy-based approach to understanding and targeting disease-causing missense mutations A Y328C missense mutation in spermine synthase causes a mild form of Snyder-Robinson syndrome.Molecular docking and molecular dynamics study on the effect of ERCC1 deleterious polymorphisms in ERCC1-XPF heterodimer.Investigation of binding phenomenon of NSP3 and p130Cas mutants and their effect on cell signalling.

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

http://www.wikidata.org/entity/Q24643464

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2009 nî lūn-bûn

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2009 թուականի Մարտին հրատարակուած գիտական յօդուած

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2009 թվականի մարտին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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J.BPJ.2008.12.3904

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Biophysical Journal

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Modeling effects of human single nucleotide polymorphisms on protein-protein interactions

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Anna Panchenko

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Emil Alexov

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Shaolei Teng

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Thomas Madej

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P2860

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders

SNPeffect: a database mapping molecular phenotypic effects of human non-synonymous coding SNPs

Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase

All-atom empirical potential for molecular modeling and dynamics studies of proteins

Principles of protein-protein interactions

Prediction of deleterious human alleles

Rapid grid-based construction of the molecular surface and the use of induced surface charge to calculate reaction field energies: applications to the molecular systems and geometric objects

SNPs, protein structure, and disease.

LS-SNP: large-scale annotation of coding non-synonymous SNPs based on multiple information sources.

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single-nucleotide polymorphism

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