An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG)
about
High Conformational Stability of Secreted Eukaryotic Catalase-peroxidases: ANSWERS FROM FIRST CRYSTAL STRUCTURE AND UNFOLDING STUDIESIsoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activitiesIsoniazid inhibits the heme-based reactivity of Mycobacterium tuberculosis truncated hemoglobin NIntermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin.Predicting Ecological Roles in the Rhizosphere Using Metabolome and Transportome ModelingTwo tyrosyl radicals stabilize high oxidation states in cytochrome C oxidase for efficient energy conservation and proton translocation.A High-Throughput Assay for Developing Inhibitors of PhoP, a Virulence Factor of Mycobacterium tuberculosisSpecific function of the Met-Tyr-Trp adduct radical and residues Arg-418 and Asp-137 in the atypical catalase reaction of catalase-peroxidase KatGBiophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an ExampleChemotherapeutic interventions against tuberculosisChallenges and opportunities in developing novel drugs for TB.Nucleoside analogs and tuberculosis: new weapons against an old enemy.Ester-prodrugs of ethambutol control its antibacterial activity and provide rapid screening for mycobacterial hydrolase activity.Biological and quantitative-SAR evaluations, and docking studies of (E)-N -benzylidenebenzohydrazide analogues as potential antibacterial agentsPulsed EPR distance measurements in soluble proteins by site-directed spin labeling (SDSL).A radical on the Met-Tyr-Trp modification required for catalase activity in catalase-peroxidase is established by isotopic labeling and site-directed mutagenesisRole of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant.A rapid freeze-quench setup for multi-frequency EPR spectroscopy of enzymatic reactions.Mutual synergy between catalase and peroxidase activities of the bifunctional enzyme KatG is facilitated by electron hole-hopping within the enzyme.Properties of Site-Specifically Incorporated 3-Aminotyrosine in Proteins To Study Redox-Active Tyrosines: Escherichia coli Ribonucleotide Reductase as a Paradigm.
P2860
Q27670871-C8D07D36-F109-4E2A-AC01-126B68F5EF05Q33836289-300F8564-ED7C-4D57-9D3B-EAC2FC3C0512Q34924586-9BA480EC-3E3A-429F-B5D7-6622DC0806D1Q35757188-55D0DC3C-865B-498C-8194-EC410FAA4759Q35762378-74306654-5625-460A-ADBD-FDD0B89C99B5Q36163649-7972D308-E513-45D7-A819-EF6A180FB319Q36164838-704BC263-22EC-4889-B9DD-1B7DA6815BF5Q36347737-22AC910D-9226-4F39-BA95-252EE09F31C4Q37057405-2D156707-E586-4A82-A177-0747D10D982DQ37148764-65C0BBD6-D31D-43FC-AB91-902B6A23E117Q37924294-43BDF564-9B29-479C-8A17-A091AAE1E6A5Q38397331-B519F7DE-B1EF-4934-8B6A-D5B57DB506ADQ40062082-261C3560-7064-47C1-AE48-1807CAFC295AQ41954593-62FB4130-3770-4EE9-A200-80AB14271B2CQ42118672-3C9A76C9-81F3-4BCE-B083-750EE9EFCCD5Q42186932-CBE8F050-009A-4433-8E6E-CC3D11D2CD45Q43167115-D9B98336-2D79-44F0-AA8C-A39AD608380EQ44412482-7467C0E9-09BD-43DE-B7DD-6A5914878A80Q46296304-ECFC0361-F3B1-47DF-85EB-05C3FA6F5081Q52328249-F406DCB1-E470-4348-9D62-6C8219520A84
P2860
An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG)
description
2009 nî lūn-bûn
@nan
2009 թուականի Մարտին հրատարակուած գիտական յօդուած
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2009 թվականի մարտին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@ast
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@en
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@nl
type
label
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@ast
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@en
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@nl
prefLabel
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@ast
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@en
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@nl
P2093
P2860
P3181
P356
P1476
An oxyferrous heme/protein-bas ...... sis catalase-peroxidase (KatG)
@en
P2093
Andrzej A Jarzecki
Gary J Gerfen
Javier Suarez
Julia Manzerova
Kalina Ranguelova
Leonid Metlitsky
Richard S Magliozzo
Shengwei Yu
Vladimir Krymov
Xiangbo Zhao
P2860
P304
P3181
P356
10.1074/JBC.M808106200
P407
P577
2009-03-13T00:00:00Z