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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

http://www.wikidata.org/entity/Q24646873

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Identification of a TPX2-like microtubule-associated protein in Drosophila Kinesin-5: cross-bridging mechanism to targeted clinical therapy Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2 TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle Non-centrosomal TPX2-Dependent Regulation of the Aurora A Kinase: Functional Implications for Healthy and Pathological Cell Division TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux.TPX2 Inhibits Eg5 by Interactions with Both Motor and Microtubule.Novel Binding of the Mitotic Regulator TPX2 (Target Protein for Xenopus Kinesin-like Protein 2) to Importin-α Pioneering the Xenopus oocyte and egg extract system.Poleward transport of TPX2 in the mammalian mitotic spindle requires dynein, Eg5, and microtubule flux.Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2.Development of a Drosophila cell-based error correction assay.Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics.Eg5 restricts anaphase B spindle elongation in mammalian cells.Mechanism and regulation of kinesin-5, an essential motor for the mitotic spindle.TPX2 levels modulate meiotic spindle size and architecture in Xenopus egg extracts.Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2.CENP-W plays a role in maintaining bipolar spindle structure.Phosphorylation of targeting protein for Xenopus kinesin-like protein 2 (TPX2) at threonine 72 in spindle assembly.Regulation of Greatwall kinase by protein stabilization and nuclear localization Mitotic Stress and Chromosomal Instability in Cancer: The Case for TPX2.Modular aspects of kinesin force generation machinery Suppression of microtubule assembly kinetics by the mitotic protein TPX2.Phosphorylation of p53 is regulated by TPX2-Aurora A in xenopus oocytes.The sequential activation of the mitotic microtubule assembly pathways favors bipolar spindle formation LIN-9 phosphorylation on threonine-96 is required for transcriptional activation of LIN-9 target genes and promotes cell cycle progression.Mitotic functions of kinesin-5.The molecular basis for kinesin functional specificity during mitosis.Measuring Pushing and Braking Forces Generated by Ensembles of Kinesin-5 Crosslinking Two Microtubules.Structural analysis of the role of TPX2 in branching microtubule nucleation.Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.Structural insight into TPX2-stimulated microtubule assembly.The plant TPX2 protein regulates prospindle assembly before nuclear envelope breakdown.She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain.P190RhoGAP prevents mitotic spindle fragmentation and is required to activate Aurora A kinase at acentriolar poles.

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

http://www.wikidata.org/entity/Q24646873

description

2008 nî lūn-bûn

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2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2008 թվականի ապրիլին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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J.CUB.2008.02.077

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Current Biology

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Spindle pole regulation by a discrete Eg5-interacting domain in TPX2

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Andrea L Lewellyn

http://www.w3.org/2001/XMLSchema#string

Claude Prigent

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Frank Eckerdt

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James L Maller

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Patrick A Eyers

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P2860

Structural basis of Aurora-A activation by TPX2 at the mitotic spindle

Anaphase-promoting complex/cyclosome controls the stability of TPX2 during mitotic exit

Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle

The mechanism of spindle assembly: functions of Ran and its target TPX2

TPX2, A novel xenopus MAP involved in spindle pole organization

Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex

hTPX2 is required for normal spindle morphology and centrosome integrity during vertebrate cell division

HURP is part of a Ran-dependent complex involved in spindle formation

The cellular geography of aurora kinases

A cytokinesis furrow is positioned by two consecutive signals.

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519-25

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18372177

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2408861

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