Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics - Wikidata - wikimedia - TriplyDB

Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics

Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics

http://www.wikidata.org/entity/Q24647687

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Isocyanide-Based Multicomponent Reactions for the Synthesis of Heterocycles Investigational peptide and peptidomimetic μ and δ opioid receptor agonists in the relief of pain Current research on opioid receptor function.Co-activation of μ- and δ-opioid receptors elicits tolerance to morphine-induced ventilatory depression via generation of peroxynitrite Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid.Designing bifunctional NOP receptor-mu opioid receptor ligands from NOP-receptor selective scaffolds. Part II.Bi- or multifunctional opioid peptide drugs.Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic.Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor trafficking Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics.The OPRD1 and OPRK1 loci in alcohol or drug dependence: OPRD1 variation modulates substance dependence risk.Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction.Opioid agonist efficacy predicts the magnitude of tolerance and the regulation of mu-opioid receptors and dynamin-2 5'-halogenated analogs of oxymorphindole.Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives.14-Alkoxy- and 14-acyloxypyridomorphinans: μ agonist/δ antagonist opioid analgesics with diminished tolerance and dependence side effects Heteroatom analogues of hydrocodone: synthesis and biological activity Pharmacological traits of delta opioid receptors: pitfalls or opportunities?Effects of N-Substitutions on the Tetrahydroquinoline (THQ) Core of Mixed-Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Ligands Molecular Pharmacology of δ-Opioid Receptors.Role of delta opioid efficacy as a determinant of mu/delta opioid interactions in rhesus monkeys.Probes for narcotic receptor mediated phenomena. 48. C7- and C8-substituted 5-phenylmorphan opioids from diastereoselective alkylation Modulation between high- and low-frequency transcutaneous electric nerve stimulation delays the development of analgesic tolerance in arthritic rats.Non-peptidic δ opioid receptor agonists and antagonists (2000 - 2012).Delta opioid agonists: a concise update on potential therapeutic applications.Molecular characterization of eluxadoline as a potential ligand targeting mu-delta opioid receptor heteromers.The design of multitarget ligands for chronic and neuropathic pain.Emerging treatments in neurogastroenterology: eluxadoline - a new therapeutic option for diarrhea-predominant IBS.In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt(1)-DALDA Analogues.Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogues in mice.Enkephalin analogues with N-phenyl-N-(piperidin-2-ylmethyl)propionamide derivatives: Synthesis and biological evaluations.Synthesis and biological evaluation of some novel 1-substituted fentanyl analogs in Swiss albino mice.Asymmetric synthesis and in vitro and in vivo activity of tetrahydroquinolines featuring a diverse set of polar substitutions at the 6 position as mixed-efficacy μ opioid receptor/δ opioid receptor ligands.Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain.In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera Effects of microRNA-223 on morphine analgesic tolerance by targeting NLRP3 in a rat model of neuropathic pain.Eluxadoline in irritable bowel syndrome with diarrhea: rationale, evidence and place in therapy.Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis.[6,7]-heterocycle-fused 14-hydroxymorphinan derivatives: design, synthesis, and opioid receptor activity.

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P2860

Opioid ligands with mixed mu/delta opioid receptor interactions: an emerging approach to novel analgesics

http://www.wikidata.org/entity/Q24647687

description

2006 nî lūn-bûn

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2006 թուականին հրատարակուած գիտական յօդուած

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2006 թվականին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

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The AAPS Journal

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Opioid ligands with mixed mu/d ...... g approach to novel analgesics

@en

P2093

Subramaniam Ananthan

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P2860

Heterodimerization of mu and delta opioid receptors: A role in opiate synergy

SNC 80 and related delta opioid agonists

Delta-opioid ligands reverse alfentanil-induced respiratory depression but not antinociception

A Role for the Distal Carboxyl Tails in Generating the Novel Pharmacology and G Protein Activation Profile of and Opioid Receptor Hetero-oligomers

Opioids: first lessons from knockout mice.

In vivo pharmacological characterization of SoRI 9409, a nonpeptidic opioid mu-agonist/delta-antagonist that produces limited antinociceptive tolerance and attenuates morphine physical dependence.

Opioids and their complicated receptor complexes.

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. II. A mixed opioid agonist with potent antinociceptive activity and limited effects on respiratory function.

DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity.

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E118-25

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scholarly article

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10.1208/AAPSJ080114

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1

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8

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2006-01-01T00:00:00Z

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7196113

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1021393514

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16584118

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2751430

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