Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation
about
FBW7-mediated ubiquitination and degradation of KLF5Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host GenomeGenetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repressionAssociation of nuclear-localized Nemo-like kinase with heat-shock protein 27 inhibits apoptosis in human breast cancer cells.Aberrant regulation of FBW7 in cancer.F-box protein FBXO31 is down-regulated in gastric cancer and negatively regulated by miR-17 and miR-20a.Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.Cullins and cancer.Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer.Emerging roles of the FBW7 tumour suppressor in stem cell differentiation.Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation.FBXW7 negatively regulates ENO1 expression and function in colorectal cancer.Tumor suppressor functions of FBW7 in cancer development and progression.Myb proteins: angels and demons in normal and transformed cells.The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformationAdenovirus E1A inhibits SCF(Fbw7) ubiquitin ligase.NLK-mediated phosphorylation of HDAC1 negatively regulates Wnt signaling.Homeodomain-interacting protein kinase 2 (HIPK2): a promising target for anti-cancer therapies.Evolutionary and comparative analysis of MYB and bHLH plant transcription factors.Recent advances in SCF ubiquitin ligase complex: Clinical implicationsFBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis.The PI3 kinase inhibitor NVP-BKM120 induces GSK3/FBXW7-dependent Mcl-1 degradation, contributing to induction of apoptosis and enhancement of TRAIL-induced apoptosis.Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.GSK3 regulates the expressions of human and mouse c-Myb via different mechanisms.Fbw7 promotes ubiquitin-dependent degradation of c-Myb: involvement of GSK3-mediated phosphorylation of Thr-572 in mouse c-Myb.Tumor suppressor Fbxw7 antagonizes WNT signaling by targeting β-catenin for degradation in pancreatic cancer.Prickle is phosphorylated by Nemo and targeted for degradation to maintain Prickle/Spiny-legs isoform balance during planar cell polarity establishment.A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity
P2860
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P2860
Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for nemo-like kinase (NLK)-induced degradation
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@ast
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@en
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@nl
type
label
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@ast
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@en
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@nl
prefLabel
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@ast
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@en
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@nl
P2093
P2860
P356
P1476
Fbxw7 acts as an E3 ubiquitin ...... nase (NLK)-induced degradation
@en
P2093
Chie Kanei-Ishii
Keiichi I Nakayama
Nobumoto Watanabe
Shunsuke Ishii
Teruaki Nomura
Tsuyoshi Takagi
P2860
P304
P356
10.1074/JBC.M804340200
P407
P577
2008-11-07T00:00:00Z