Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice - Wikidata - wikimedia - TriplyDB

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

http://www.wikidata.org/entity/Q24651541

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Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication The 22q13.3 Deletion Syndrome (Phelan-McDermid Syndrome)Emerging pharmacotherapies for neurodevelopmental disorders Epigenetics in the mature mammalian brain: effects on behavior and synaptic transmission The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia.Recent advances in understanding synaptic abnormalities in Rett syndrome Developmental Dynamics of Rett Syndrome Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders Understanding the molecular basis of autism in a dish using hiPSCs-derived neurons from ASD patients MECP2 disorders: from the clinic to mice and back Modeling neurodevelopmental disorders using human neurons iPSC-derived neurons as a higher-throughput readout for autism: promises and pitfalls Following the genes: a framework for animal modeling of psychiatric disorders Networking in autism: leveraging genetic, biomarker and model system findings in the search for new treatments The impact of MeCP2 loss- or gain-of-function on synaptic plasticity Dendritic spine dysgenesis in autism related disorders BDNF deregulation in Rett syndrome GABAergic signaling as therapeutic target for autism spectrum disorders Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes Role of mecp2 in experience-dependent epigenetic programming MeCP2 Affects Skeletal Muscle Growth and Morphology through Non Cell-Autonomous Mechanisms Illness Severity, Social and Cognitive Ability, and EEG Analysis of Ten Patients with Rett Syndrome Treated with Mecasermin (Recombinant Human IGF-1).Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex.Rett Syndrome: Reaching for Clinical Trials From "directed differentiation" to "neuronal induction": modeling neuropsychiatric disease Insulin-Like Growth Factor 1 and Related Compounds in the Treatment of Childhood-Onset Neurodevelopmental Disorders Advancing the understanding of autism disease mechanisms through genetics A review of Rett syndrome (RTT) with induced pluripotent stem cells A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons.SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients Translational Mouse Models of Autism: Advancing Toward Pharmacological Therapeutics.Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat A critical and cell-autonomous role for MeCP2 in synaptic scaling up A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli.Therapeutic Potential of Transcranial Focused Ultrasound for Rett Syndrome.Microglia as a critical player in both developmental and late-life CNS pathologies.The role of microglia in brain maintenance: implications for Rett syndrome.Wild-type microglia arrest pathology in a mouse model of Rett syndrome.Insulinotropic treatments exacerbate metabolic syndrome in mice lacking MeCP2 function.

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P2860

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

http://www.wikidata.org/entity/Q24651541

description

2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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type

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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prefLabel

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

@en

Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Proceedings of the National Academy of Sciences of the United States of America

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Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice

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Caroline Beard

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Cortina McCurry

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Dong Dong Fu

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Mriganka Sur

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Nathan R Wilson

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Ruth Flannery

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P2860

Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2

Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett syndrome

MeCP2, a key contributor to neurological disease, activates and represses transcription

The story of Rett syndrome: from clinic to neurobiology

A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome

Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome

MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number

Mecp2 deficiency leads to delayed maturation and altered gene expression in hippocampal neurons

Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2

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