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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

Reaction discovery enabled by DNA-templated synthesis and in vitro selection

http://www.wikidata.org/entity/Q24655435

about

Effects of template sequence and secondary structure on DNA-templated reactivity New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries Conversion of DNA methyltransferases into azidonucleosidyl transferases via synthetic cofactors A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA Covalent attachment of lipid vesicles to a fluid-supported bilayer allows observation of DNA-mediated vesicle interactions.Interaction-dependent PCR: identification of ligand-target pairs from libraries of ligands and libraries of targets in a single solution-phase experiment.Enzymatic aminoacylation of tRNA with unnatural amino acids.Tandem driven dynamic combinatorial resolution via Henry-iminolactone rearrangement.Reactivity-dependent PCR: direct, solution-phase in vitro selection for bond formation.Multicomponent reaction discovery: three-component synthesis of spirooxindoles.An in vitro translation, selection and amplification system for peptide nucleic acids Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.In vitro selection of a DNA-templated small-molecule library reveals a class of macrocyclic kinase inhibitors A sequential strand-displacement strategy enables efficient six-step DNA-templated synthesis.Small-molecule discovery from DNA-encoded chemical libraries.Facile construction of nanofibers as a functional template for surface boron coordination reaction.Hydrazide reactive peptide tags for site-specific protein labeling.Three-component reaction discovery enabled by mass spectrometry of self-assembled monolayers A Reactivity-Driven Approach to the Discovery and Development of Gold-Catalyzed Organic Reactions.Effective molarity redux: Proximity as a guiding force in chemistry and biology.Label-assisted mass spectrometry for the acceleration of reaction discovery and optimization Prospective identification of parasitic sequences in phage display screens.Multidimensional reaction screening for photochemical transformations as a tool for discovering new chemotypes.Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones.Novel selection methods for DNA-encoded chemical libraries Enzyme immunoassays as screening tools for catalysts and reaction discovery.Photon-regulated DNA-enzymatic nanostructures by molecular assembly.DNA-Encoded Dynamic Combinatorial Chemical Libraries.Chemistry of nucleic acids: impacts in multiple fields.Discovery of an α-amino C-H arylation reaction using the strategy of accelerated serendipity.DNA as a versatile chemical component for catalysis, encoding, and stereocontrol DNA micelles as nanoreactors: efficient DNA functionalization with hydrophobic organic molecules.Achievements, Challenges, and Opportunities in DNA-Encoded Library Research: An Academic Point of View.Designed DNA molecules: principles and applications of molecular nanotechnology.Speeding up biomolecular interactions by molecular sledding.A Template-Mediated Click-Click Reaction: PNA-DNA, PNA-PNA (or Peptide) Ligation, and Single Nucleotide Discrimination.Effective molarity in a nucleic acid-controlled reaction Covalent capture: merging covalent and noncovalent synthesis.Rapid and specific post-synthesis modification of DNA through a biocompatible condensation of 1,2-aminothiols with 2-cyanobenzothiazole.

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

http://www.wikidata.org/entity/Q24655435

description

2004 nî lūn-bûn

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2004 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

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Reaction discovery enabled by DNA-templated synthesis and in vitro selection

@en

P2093

David R Liu

http://www.w3.org/2001/XMLSchema#string

Kaori Sakurai

http://www.w3.org/2001/XMLSchema#string

Mary M Rozenman

http://www.w3.org/2001/XMLSchema#string

Matthew W Kanan

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P2860

The generality of DNA-templated synthesis as a basis for evolving non-natural small molecules

Biomimetic synthesis and optimization of cyclic peptide antibiotics

A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

Combinatorial and Evolution-Based Methods in the Creation of Enantioselective Catalysts.

Thermographic selection of effective catalysts from an encoded polymer-bound library

In vitro selection of functional nucleic acids.

Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis.

Directed evolution of nucleic acid enzymes.

Polyketide biosynthesis: a millennium review.

Proton-activated fluorescence as a tool for simultaneous screening of combinatorial chemical reactions.

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545-549

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10.1038/NATURE02920

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7008

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431

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Thomas M Snyder

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2004-09-01T00:00:00Z

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8258757

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1007326774

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15457254

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2814052

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