Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin - Wikidata - wikimedia - TriplyDB

Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin

Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin

http://www.wikidata.org/entity/Q24656027

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Pain as a channelopathy New molecular targets for antiepileptic drugs: alpha(2)delta, SV2A, and K(v)7/KCNQ/M potassium channels Mechanisms of the gabapentinoids and α 2 δ-1 calcium channel subunit in neuropathic pain The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential Structure-function of proteins interacting with the α1 pore-forming subunit of high-voltage-activated calcium channels Mutant PrP suppresses glutamatergic neurotransmission in cerebellar granule neurons by impairing membrane delivery of VGCC α(2)δ-1 Subunit Molecular mechanisms of antiseizure drug activity at GABAA receptors Characterization of the first honeybee Ca²⁺ channel subunit reveals two novel species- and splicing-specific modes of regulation of channel inactivation.Emerging evidence for specific neuronal functions of auxiliary calcium channel α₂δ subunits.PHARMACOLOGICAL TREATMENTS FOR TINNITUS: NEW AND OLD Pregabalin modulation of neurotransmitter release is mediated by change in intrinsic activation/inactivation properties of ca(v)2.1 calcium channels.Tri-partite complex for axonal transport drug delivery achieves pharmacological effect.Presynaptic CaV2 calcium channel traffic requires CALF-1 and the alpha(2)delta subunit UNC-36 The alpha2delta subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for function Identification of a disulfide bridge essential for structure and function of the voltage-gated Ca(2+) channel α(2)δ-1 auxiliary subunit.Regulation of high-voltage-activated Ca(2+) channel function, trafficking, and membrane stability by auxiliary subunits.Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits.Inactivation of L-type calcium channel modulated by HCN2 channel Gabapentin enacarbil - clinical efficacy in restless legs syndrome Sigma-1 receptor antagonism restores injury-induced decrease of voltage-gated Ca2+ current in sensory neurons The use of ketamine in complex regional pain syndrome: possible mechanisms.Gabapentin attenuates hyperexcitability in the freeze-lesion model of developmental cortical malformation.Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond.Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states.Painful nerve injury upregulates thrombospondin-4 expression in dorsal root ganglia Alpha 2 Delta (α(2)δ) Ligands, Gabapentin and Pregabalin: What is the Evidence for Potential Use of These Ligands in Irritable Bowel Syndrome Gabapentin administration reduces reactive gliosis and neurodegeneration after pilocarpine-induced status epilepticus.Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ α2δ-1 subunit Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin.Neurocognitive performance, alcohol withdrawal, and effects of a combination of flumazenil and gabapentin in alcohol dependence.Riluzole and gabapentinoids activate glutamate transporters to facilitate glutamate-induced glutamate release from cultured astrocytes.Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology.Gabapentin prevents oxaliplatin-induced central sensitization in the dorsal horn neurons in rats Gabapentin inhibits catecholamine release from adrenal chromaffin cells Drug management of visceral pain: concepts from basic research.Nerve injury-induced calcium channel alpha-2-delta-1 protein dysregulation leads to increased pre-synaptic excitatory input into deep dorsal horn neurons and neuropathic allodynia Gabapentin inhibits γ-amino butyric acid release in the locus coeruleus but not in the spinal dorsal horn after peripheral nerve injury in rats Acute augmentation of epoxygenated fatty acid levels rapidly reduces pain-related behavior in a rat model of type I diabetes.Chronic pregabalin inhibits synaptic transmission between rat dorsal root ganglion and dorsal horn neurons in culture.Molecular Basis of Regulating High Voltage-Activated Calcium Channels by S-Nitrosylation.

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Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin

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Alexandra Tran Van Minh

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Anthony Davies

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Fay Heblich

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Jack Wratten

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Jan Hendrich

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Manuela Nieto-Rostro

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P2860

Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere

Structure and regulation of voltage-gated Ca2+ channels

Down-regulation of N-type voltage-activated Ca2+ channels by gabapentin

Block by gabapentin of the facilitation of glutamate release from rat trigeminal nucleus following activation of protein kinase C or adenylyl cyclase

Identification of LAT4, a novel amino acid transporter with system L activity

Calcium channel alpha2delta subunits: differential expression, function, and drug binding

The metal-ion-dependent adhesion site in the Von Willebrand factor-A domain of alpha2delta subunits is key to trafficking voltage-gated Ca2+ channels.

Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein.

Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.

Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery.

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