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The ABC protein turned chloride channel whose failure causes cystic fibrosis

The ABC protein turned chloride channel whose failure causes cystic fibrosis

http://www.wikidata.org/entity/Q24657572

about

Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase Chloride channels as drug targets.Visualizing functional motions of membrane transporters with molecular dynamics simulations The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology Integrated analysis of residue coevolution and protein structure in ABC transporters Thermodynamics of ABC transporters Insights into How Nucleotide-Binding Domains Power ABC Transport Structures of a minimal human CFTR first nucleotide-binding domain as a monomer, head-to-tail homodimer, and pathogenic mutant Biochemical Basis of the Interaction between Cystic Fibrosis Transmembrane Conductance Regulator and Immunoglobulin-like Repeats of Filamin Homologue structure of the SLAC1 anion channel for closing stomata in leaves The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): THREE-DIMENSIONAL STRUCTURE AND LOCALIZATION OF A CHANNEL GATE Structure of a periplasmic glucose-binding protein fromThermotoga maritima Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.A Pore Idea: the ion conduction pathway of TMEM16/ANO proteins is composed partly of lipid Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives CFTR Modulators: Shedding Light on Precision Medicine for Cystic Fibrosis The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity Dysfunction of Nrf-2 in CF epithelia leads to excess intracellular H2O2 and inflammatory cytokine production Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications Impact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.New insights into interactions between the nucleotide-binding domain of CFTR and keratin 8.Development of CFTR Structure Monomeric CFTR in plasma membranes in live cells revealed by single molecule fluorescence imaging.The Concise Guide to PHARMACOLOGY 2013/14: ion channels ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.Bdellovibrio bacteriovorus directly attacks Pseudomonas aeruginosa and Staphylococcus aureus Cystic fibrosis isolates.Deletion of CFTR translation start site reveals functional isoforms of the protein in CF patients.Design and synthesis of a hybrid potentiator-corrector agonist of the cystic fibrosis mutant protein DeltaF508-CFTR The solute carrier 26 family of proteins in epithelial ion transport.AtMRP6/AtABCC6, an ATP-binding cassette transporter gene expressed during early steps of seedling development and up-regulated by cadmium in Arabidopsis thaliana Monocytes from cystic fibrosis patients are locked in an LPS tolerance state: down-regulation of TREM-1 as putative underlying mechanism.A multidrug ABC transporter with a taste for salt.Asymmetric switching in a homodimeric ABC transporter: a simulation study Folding and rescue of a cystic fibrosis transmembrane conductance regulator trafficking mutant identified using human-murine chimeric proteins Genetic variation and clinical heterogeneity in cystic fibrosis CFTR and TNR-CFTR expression and function in the kidney.Cystic fibrosis: exploiting its genetic basis in the hunt for new therapies CFTR: break a pump, make a channel Alteration of protein function by a silent polymorphism linked to tRNA abundance.

P2860

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P2860

The ABC protein turned chloride channel whose failure causes cystic fibrosis

http://www.wikidata.org/entity/Q24657572

description

2006 nî lūn-bûn

@nan

2006 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի մարտին հրատարակված գիտական հոդված

@hy

2006年の論文

@ja

2006年論文

@yue

2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

@zh-mo

2006年論文

@zh-tw

2006年论文

@wuu

name

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@ast

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@en

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@nl

type

label

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@ast

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@en

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@nl

prefLabel

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@ast

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@en

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@nl

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P1476

The ABC protein turned chloride channel whose failure causes cystic fibrosis

@en

P2093

David C Gadsby

http://www.w3.org/2001/XMLSchema#string

P2860

Identification of the cystic fibrosis gene: chromosome walking and jumping

H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

Cooperative, ATP-dependent association of the nucleotide binding cassettes during the catalytic cycle of ATP-binding cassette transporters

CFTR gating II: Effects of nucleotide binding on the stability of open states

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

P2888

P304

477-83

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scholarly article

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106815

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10.1038/NATURE04712

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7083

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440

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László Csanády

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2006-03-23T00:00:00Z

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7224018

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1011595018

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16554808

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P921

cystic fibrosis

P932

2720541

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