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Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

http://www.wikidata.org/entity/Q24658271

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Genetic determinants and potential therapeutic targets for pancreatic adenocarcinoma Genome-wide association study of pancreatic cancer in Japanese population Analysis of heritability and shared heritability based on genome-wide association studies for thirteen cancer types Structural basis for recruitment of BRCA2 by PALB2 A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33 Patient-derived tumour xenografts as models for oncology drug development International network of cancer genome projects.Targeted capture and massively parallel sequencing of 12 human exomes Recent progress in pancreatic cancer Susceptibility pathways in Fanconi's anemia and breast cancer Review of screening for pancreatic cancer in high risk individuals Identifying druggable disease-modifying gene products Surgical and molecular pathology of pancreatic neoplasms Clinical Genetic Testing in Gastroenterology Molecular therapeutics in pancreas cancer Pancreatic Cancer Genetics The Landscape of Pancreatic Cancer Therapeutic Resistance Mechanisms Genetics and biology of pancreatic ductal adenocarcinoma Genomic alterations in pancreatic cancer and their relevance to therapy Pancreatic adenocarcinoma pathology: changing "landscape"Familial Pancreatic Adenocarcinoma Epidemiology and Inherited Predisposition for Sporadic Pancreatic Adenocarcinoma Molecular landscape of pancreatic cancer: implications for current clinical trials Inherited pancreatic cancer syndromes Genetic basis of pancreas cancer development and progression: insights from whole-exome and whole-genome sequencing Endoscopic ultrasonography for surveillance of individuals at high risk for pancreatic cancer Systemic therapies for pancreatic cancer--the role of pharmacogenetics Pancreatic cancer early detection: expanding higher-risk group with clinical and metabolomics parameters Human correlates of provocative questions in pancreatic pathology Squamous cell carcinomas of the head and neck in Fanconi anemia: risk, prevention, therapy, and the need for guidelines Personalizing cancer treatment in the age of global genomic analyses: PALB2 gene mutations and the response to DNA damaging agents in pancreatic cancer.The genetic heterogeneity of colorectal cancer predisposition - guidelines for gene discovery Homologous recombination and human health: the roles of BRCA1, BRCA2, and associated proteins PALB2: the hub of a network of tumor suppressors involved in DNA damage responses Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene Cooperation of breast cancer proteins PALB2 and piccolo BRCA2 in stimulating homologous recombination Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics Loss of p53 partially rescues embryonic development of Palb2 knockout mice but does not foster haploinsufficiency of Palb2 in tumour suppression

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Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

http://www.wikidata.org/entity/Q24658271

description

2009 nî lūn-bûn

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2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի ապրիլին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@ast

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@en

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@nl

type

label

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@ast

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@en

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@nl

prefLabel

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@ast

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@en

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

@nl

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SCIENCE.1171202

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Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene

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Alison P Klein

http://www.w3.org/2001/XMLSchema#string

Anirban Maitra

http://www.w3.org/2001/XMLSchema#string

D Williams Parsons

http://www.w3.org/2001/XMLSchema#string

Emily Palmisano

http://www.w3.org/2001/XMLSchema#string

Giovanni Parmigiani

http://www.w3.org/2001/XMLSchema#string

James R Eshleman

http://www.w3.org/2001/XMLSchema#string

Jimmy Cheng-Ho Lin

http://www.w3.org/2001/XMLSchema#string

Kieran Brune

http://www.w3.org/2001/XMLSchema#string

Michael Borges

http://www.w3.org/2001/XMLSchema#string

Mihoko Kamiyama

http://www.w3.org/2001/XMLSchema#string

P2860

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

An integrated genomic analysis of human glioblastoma multiforme

The genomic landscapes of human breast and colorectal cancers

Pancreatic cancer.

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

Genetic predisposition to breast cancer: past, present, and future.

Medicine. The future of personal genomics.

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scholarly article

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982376

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10.1126/SCIENCE.1171202

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5924

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324

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Ralph H. Hruban

Kenneth W Kinzler

Elizabeth Jaffee

Christine A Iacobuzio-Donahue

Michael Goggins

Victor Velculescu

Bert Vogelstein

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2009-04-10T00:00:00Z

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24180826

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19264984

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2684332

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