Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells
about
Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.While at Rome miRNA and TRAIL do whatever BCR-ABL commands to do.Targeting homologous recombination-mediated DNA repair in cancer.Monoubiquitinated Fanconi anemia D2 (FANCD2-Ub) is required for BCR-ABL1 kinase-induced leukemogenesis.BCR/ABL stimulates WRN to promote survival and genomic instability.HDAC1,2 inhibition and doxorubicin impair Mre11-dependent DNA repair and DISC to override BCR-ABL1-driven DSB repair in Philadelphia chromosome-positive B-cell precursor acute lymphoblastic leukemia.
P2860
Enhanced phosphorylation of Nbs1, a member of DNA repair/checkpoint complex Mre11-RAD50-Nbs1, can be targeted to increase the efficacy of imatinib mesylate against BCR/ABL-positive leukemia cells
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2007 nî lūn-bûn
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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հուլիսին հրատարակված գիտական հոդված
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2007年の論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年論文
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2007年论文
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name
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@ast
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@en
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@nl
type
label
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@ast
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@en
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@nl
prefLabel
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@ast
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@en
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@nl
P2093
P2860
P921
P1433
P1476
Enhanced phosphorylation of Nb ...... CR/ABL-positive leukemia cells
@en
P2093
Artur Slupianek
Ilona Seferynska
Katarzyna Urbanska
Krzysztof Reiss
Margaret Nieborowska-Skorska
Tomasz Skorski
P2860
P304
P356
10.1182/BLOOD-2006-08-042630
P407
P577
2007-07-15T00:00:00Z