Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5 - Wikidata - wikimedia - TriplyDB

Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5

Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5

http://www.wikidata.org/entity/Q24670878

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GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors RGS9-2: probing an intracellular modulator of behavior as a drug target.The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling μ-Opioid receptors and regulators of G protein signaling (RGS) proteins: from a symposium on new concepts in mu-opioid pharmacology Regulators of G-protein signaling in the heart and their potential as therapeutic targets.Phosducin-like protein 1 is essential for G-protein assembly and signaling in retinal rod photoreceptors R7BP augments the function of RGS7*Gbeta5 complexes by a plasma membrane-targeting mechanism R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse Palmitoylation regulates plasma membrane-nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family.Multiple actions of spinophilin regulate mu opioid receptor function Light-induced translocation of RGS9-1 and Gβ5L in mouse rod photoreceptors G protein beta 5 is targeted to D2-dopamine receptor-containing biochemical compartments and blocks dopamine-dependent receptor internalization RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons Association between regulator of G protein signaling 9-2 and body weight Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins.The evolution of regulators of G protein signalling proteins as drug targets - 20 years in the making: IUPHAR Review 21.Regulator of G protein signaling 6 (RGS6) protein ensures coordination of motor movement by modulating GABAB receptor signaling.Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP.Membrane anchor R9AP potentiates GTPase-accelerating protein activity of RGS11 x Gbeta5 complex and accelerates inactivation of the mGluR6-G(o) signaling.Deactivation mechanisms of rod phototransduction: the Cogan lecture.Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons.Functional redundancy of R7 RGS proteins in ON-bipolar cell dendrites RGS7 and -11 complexes accelerate the ON-bipolar cell light response.Phototransduction in mouse rods and cones.Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis.Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein.Differential effects of the Gβ5-RGS7 complex on muscarinic M3 receptor-induced Ca2+ influx and release.Thinking outside of the "RGS box": new approaches to therapeutic targeting of regulators of G protein signaling.A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins.R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells Helix 8 and the i3 loop of the muscarinic M3 receptor are crucial sites for its regulation by the Gβ5-RGS7 complex.Retinal cone photoreceptors require phosducin-like protein 1 for G protein complex assembly and signaling Rhodopsin kinase and recoverin modulate phosphodiesterase during mouse photoreceptor light adaptation.Regulator of G protein signaling 6 is a critical mediator of both reward-related behavioral and pathological responses to alcohol Knockout of G protein β5 impairs brain development and causes multiple neurologic abnormalities in mice.Targeted deletion of one or two copies of the G protein β subunit Gβ5 gene has distinct effects on body weight and behavior in mice.Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors Regulators of G protein signaling (RGS) proteins as drug targets: modulating G-protein-coupled receptor (GPCR) signal transduction

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Instability of GGL domain-containing RGS proteins in mice lacking the G protein beta-subunit Gbeta5

http://www.wikidata.org/entity/Q24670878

description

2003 nî lūn-bûn

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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2003 թվականի մայիսին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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name

Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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type

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

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PNAS.0631825100

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Instability of GGL domain-cont ...... G protein beta-subunit Gbeta5

@en

P2093

Ching-Kang Chen

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Haikun Zhang

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Melvin I Simon

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Pamela Eversole-Cire

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Valeria Mancino

http://www.w3.org/2001/XMLSchema#string

Wei He

http://www.w3.org/2001/XMLSchema#string

Yu-Jiun Chen

http://www.w3.org/2001/XMLSchema#string

P2860

A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits

High expression levels in cones of RGS9, the predominant GTPase accelerating protein of rods

Gbeta5 prevents the RGS7-Galphao interaction through binding to a distinct Ggamma-like domain found in RGS7 and other RGS proteins

Fidelity of G protein beta-subunit association by the G protein gamma-subunit-like domains of RGS6, RGS7, and RGS11

Interaction between RGS7 and polycystin

Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit).

Structure, alternative splicing, and expression of the human RGS9 gene

Modulation of the affinity and selectivity of RGS protein interaction with G alpha subunits by a conserved asparagine/serine residue

GTPase-activating proteins for heterotrimeric G proteins: regulators of G protein signaling (RGS) and RGS-like proteins

RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6

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6604-6609

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scholarly article

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2114990

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10.1073/PNAS.0631825100

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11

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100

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Theodore G. Wensel

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2003-05-08T00:00:00Z

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10766971

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12738888

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164494

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