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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

http://www.wikidata.org/entity/Q24671845

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The Role of the DNA Damage Response throughout the Papillomavirus Life Cycle Analysis of the papillomavirus E2 and bromodomain protein Brd4 interaction using bimolecular fluorescence complementation Destabilization of TIP60 by human papillomavirus E6 results in attenuation of TIP60-dependent transcriptional regulation and apoptotic pathway.Mining RNA-seq data for infections and contaminations.Papillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome.Abrogation of the Brd4-positive transcription elongation factor B complex by papillomavirus E2 protein contributes to viral oncogene repression Papillomaviruses: a systematic review.Papillomavirus interaction with cellular chromatin.Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression NCoR1 mediates papillomavirus E8;E2C transcriptional repression Brd4 is displaced from HPV replication factories as they expand and amplify viral DNA The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma Virology and molecular pathogenesis of HPV (human papillomavirus)-associated oropharyngeal squamous cell carcinoma Dimerization of the papillomavirus E2 protein is required for efficient mitotic chromosome association and Brd4 binding.Failure to interact with Brd4 alters the ability of HPV16 E2 to regulate host genome expression and cellular movement Current understanding of the role of the Brd4 protein in the papillomavirus lifecycle.The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters.The papillomavirus E2 proteins Tandemly Integrated HPV16 Can Form a Brd4-Dependent Super-Enhancer-Like Element That Drives Transcription of Viral Oncogenes Brd4 regulation of papillomavirus protein E2 stability.Brd4 Activates Early Viral Transcription upon Human Papillomavirus 18 Infection of Primary Keratinocytes.Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2.Tumor suppressor or oncogene? A critical role of the human papillomavirus (HPV) E2 protein in cervical cancer progression.Therapeutics Targeting Protein Acetylation Perturb Latency of Human Viruses.The Nuclear DNA Sensor IFI16 Acts as a Restriction Factor for Human Papillomavirus Replication through Epigenetic Modifications of the Viral Promoters.The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response.Functional effects of sequence variations in the E6 and E2 genes of human papillomavirus 16 European and Asian variants.Triggering of death receptor apoptotic signaling by human papillomavirus 16 E2 protein in cervical cancer cell lines is mediated by interaction with c-FLIP.The transcription factors TBX2 and TBX3 interact with human papillomavirus 16 (HPV16) L2 and repress the long control region of HPVs Topography of bovine papillomavirus E2 protein on the viral genome during the cell cycle.Modification of papillomavirus E2 proteins by the small ubiquitin-like modifier family members (SUMOs).Dimerization of the human papillomavirus type 16 E2 N terminus results in DNA looping within the upstream regulatory region.Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4.HPV-16 E2 contributes to induction of HPV-16 late gene expression by inhibiting early polyadenylation.HPV Replication Regulation by Acetylation of a Conserved Lysine in the E2 Protein.Regulation of the human papillomavirus type 16 late promoter by E7 and the cell cycle.BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo.

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

http://www.wikidata.org/entity/Q24671845

description

2007 nî lūn-bûn

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2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年学术文章

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2007年学术文章

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2007年学术文章

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2007年学术文章

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name

Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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prefLabel

Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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Journal of Virology

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Brd4-independent transcriptional repression function of the papillomavirus e2 proteins

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P2093

Jianxin You

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Matthias Ottinger

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Michal-Ruth Schweiger

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P2860

Mediator of Transcriptional Regulation

cAMP response element-binding protein-binding protein binds to human papillomavirus E2 protein and activates E2-dependent transcription

A bromodomain protein, MCAP, associates with mitotic chromosomes and affects G(2)-to-M transition

Amino acid substitutions that specifically impair the transcriptional activity of papillomavirus E2 affect binding to the long isoform of Brd4

The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription

The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4.

Expression of the papillomavirus E2 protein in HeLa cells leads to apoptosis

A Mammalian bromodomain protein, brd4, interacts with replication factor C and inhibits progression to S phase

Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation function

Direct interaction between nucleosome assembly protein 1 and the papillomavirus E2 proteins involved in activation of transcription

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10.1128/JVI.00447-07

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18

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81

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17626100

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