Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5 - Wikidata - wikimedia - TriplyDB

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

http://www.wikidata.org/entity/Q24672142

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The ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin motifs) family ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview The Function and Roles of ADAMTS-7 in Inflammatory Diseases Genetically Engineered Mouse Models Reveal the Importance of Proteases as Osteoarthritis Drug Targets Structure analysis reveals the flexibility of the ADAMTS-5 active site Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T Structure of human ADAM-8 catalytic domain complexed with batimastat Allosteric activation of ADAMTS13 by von Willebrand factor.ADAMTS13 and von Willebrand factor interactions.The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3.Molecular models of the Mojave rattlesnake (Crotalus scutulatus scutulatus) venom metalloproteinases reveal a structural basis for differences in hemorrhagic activities Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis.Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor.ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis.Determinants of versican-V1 proteoglycan processing by the metalloproteinase ADAMTS5 Reactive-site mutants of N-TIMP-3 that selectively inhibit ADAMTS-4 and ADAMTS-5: biological and structural implications Mechanism of von Willebrand factor scissile bond cleavage by a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 (ADAMTS13).Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)A Novel Genome-Wide Association Study Approach Using Genotyping by Exome Sequencing Leads to the Identification of a Primary Open Angle Glaucoma Associated Inversion Disrupting ADAMTS17.A smallest 6 kda metalloprotease, mini-matrilysin, in living world: a revolutionary conserved zinc-dependent proteolytic domain- helix-loop-helix catalytic zinc binding domain (ZBD).Rearranging exosites in noncatalytic domains can redirect the substrate specificity of ADAMTS proteases.Metabolic Response of Human Osteoarthritic Cartilage to Biochemically Characterized Collagen Hydrolysates.ADAMTS13 and 15 are not regulated by the full length and N-terminal domain forms of TIMP-1, -2, -3 and -4.A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers Linker regions and flexibility around the metalloprotease domain account for conformational activation of ADAMTS-13.Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity.Emerging Roles of ADAMTSs in Angiogenesis and Cancer.Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5.Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13.Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor.Structural characterization of the ectodomain of a disintegrin and metalloproteinase-22 (ADAM22), a neural adhesion receptor instead of metalloproteinase: insights on ADAM function Unusual life cycle and impact on microfibril assembly of ADAMTS17, a secreted metalloprotease mutated in genetic eye disease.Advances in the development of novel aggrecanase inhibitors.Enzymatic toxins from snake venom: structural characterization and mechanism of catalysis.Inhibition of aggrecanases as a therapeutic strategy in osteoarthritis.Pharmacophore development and screening for discovery of potential inhibitors of ADAMTS-4 for osteoarthritis therapy.The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity.Molecular basis for the mechanism of action of an anti-TACE antibody.Design, synthesis, and preliminary biological evaluation of pyrrolo[3,4-c]quinolin-1-one and oxoisoindoline derivatives as aggrecanase inhibitors.Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

http://www.wikidata.org/entity/Q24672142

description

2008 nî lūn-bûn

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2008 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2008 թվականի հունվարին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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type

label

Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Protein Science

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

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Bethany Freeman

http://www.w3.org/2001/XMLSchema#string

Christopher Corcoran

http://www.w3.org/2001/XMLSchema#string

Edward R Lavallie

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Erica L Reifenberg

http://www.w3.org/2001/XMLSchema#string

Katy Georgiadis

http://www.w3.org/2001/XMLSchema#string

Kristine Svenson

http://www.w3.org/2001/XMLSchema#string

Laura Lin

http://www.w3.org/2001/XMLSchema#string

Lidia Mosyak

http://www.w3.org/2001/XMLSchema#string

Lisa A Collins-Racie

http://www.w3.org/2001/XMLSchema#string

Mark Stahl

http://www.w3.org/2001/XMLSchema#string

P2860

Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

Aggrecanases and cartilage matrix degradation

Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

Coot: model-building tools for molecular graphics

Likelihood-enhanced fast translation functions

The CCP4 suite: programs for protein crystallography

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans

Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations.

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16-21

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1584421

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10.1110/PS.073287008

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1

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17

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2008-01-01T00:00:00Z

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5804578

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18042673

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crystal structure

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2144589

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