Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1
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Cyclin-dependent kinase 5 activity is required for T cell activation and induction of experimental autoimmune encephalomyelitisNociceptive TRP Channels: Sensory Detectors and Transducers in Multiple Pain PathologiesN-terminal tetrapeptide T/SPLH motifs contribute to multimodal activation of human TRPA1 channelHuman keratinocytes are vanilloid resistantConditional deletion of neuronal cyclin-dependent kinase 5 in developing forebrain results in microglial activation and neurodegeneration.Cdk5 activity in the brain - multiple paths of regulation.Increased synaptophysin is involved in inflammation-induced heat hyperalgesia mediated by cyclin-dependent kinase 5 in rats.Molecular Roles of Cdk5 in Pain SignalingResveratrol inhibits Cdk5 activity through regulation of p35 expressionDifferences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controlsCyclin-dependent kinase 5 regulates E2F transcription factor through phosphorylation of Rb protein in neuronsTransforming growth factor-β1 regulates Cdk5 activity in primary sensory neurons.Nociception and inflammatory hyperalgesia evaluated in rodents using infrared laser stimulation after Trpv1 gene knockout or resiniferatoxin lesionCyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-RasTRPV1 function is modulated by Cdk5-mediated phosphorylation: insights into the molecular mechanism of nociceptionModulating Innate and Adaptive Immunity by (R)-Roscovitine: Potential Therapeutic Opportunity in Cystic Fibrosis.Acute Effects of Transforming Growth Factor-β1 on Neuronal Excitability and Involvement in the Pain of Rats with Chronic PancreatitisTargeted overexpression of tumor necrosis factor-α increases cyclin-dependent kinase 5 activity and TRPV1-dependent Ca2+ influx in trigeminal neuronsTGF-β1 sensitizes TRPV1 through Cdk5 signaling in odontoblast-like cells.Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1)Tumor necrosis factor-alpha regulates cyclin-dependent kinase 5 activity during pain signaling through transcriptional activation of p35.Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue.GDNF hyperalgesia is mediated by PLCgamma, MAPK/ERK, PI3K, CDK5 and Src family kinase signaling and dependent on the IB4-binding protein versican.Conditional deletion of cyclin-dependent kinase 5 in primary sensory neurons leads to atypical skin lesions.Roles of transient receptor potential channels in pain.Activation of cyclin-dependent kinase 5 mediates orofacial mechanical hyperalgesia.Cdk5: mediator of neuronal development, death and the response to DNA damage.Trafficking of ThermoTRP Channels.Sensory TRP channels: the key transducers of nociception and pain.Cdk5: An Emerging Kinase in Pain SignalingStructural Bioinformatics Approach of Cyclin-Dependent Kinases 1 and 3 Complexed with Inhibitors.A gradient of 2-arachidonoylglycerol regulates mouse epididymal sperm cell start-up.Distinct modulations of human capsaicin receptor by protons and magnesium through different domains.The BDNF/TrkB signaling pathway is involved in heat hyperalgesia mediated by Cdk5 in rats.ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity[EXPRESS] Peripheral and orofacial pain sensation is unaffected by the loss of p39.Modulation of TRPA1 channel activity by Cdk5 in Sensory neurons.Cyclin-dependent kinase 5 modulates the P2X2a receptor channel gating through phosphorylation of C-terminal threonine 372.Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception.TNF-α Increases Production of Reactive Oxygen Species through Cdk5 Activation in Nociceptive Neurons.
P2860
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P2860
Cyclin-dependent kinase 5 modulates nociceptive signaling through direct phosphorylation of transient receptor potential vanilloid 1
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@ast
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@en
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@nl
type
label
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@ast
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@en
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@nl
prefLabel
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@ast
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@en
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@nl
P2093
P2860
P921
P3181
P356
P1476
Cyclin-dependent kinase 5 modu ...... receptor potential vanilloid 1
@en
P2093
Ashok B Kulkarni
Harish C Pant
Jason Keller
Michael J Iadarola
Nitin Agarwal
Rohini Kuner
Roscoe O Brady
Sashi Kesavapany
Tej K Pareek
P2860
P3181
P356
10.1073/PNAS.0609916104
P407
P50
P577
2007-01-09T00:00:00Z