Mismatch repair deficiency associated with overexpression of the MSH3 gene - Wikidata - wikimedia - TriplyDB

Mismatch repair deficiency associated with overexpression of the MSH3 gene

Mismatch repair deficiency associated with overexpression of the MSH3 gene

http://www.wikidata.org/entity/Q24681589

about

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSα Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci Unbalanced replication as a major source of genetic instability in cancer cells DNA triplet repeat expansion and mismatch repair A MutSβ-Dependent Contribution of MutSα to Repeat Expansions in Fragile X Premutation Mice?New insights into the mechanism of DNA mismatch repair DNA mismatch repair and mutation avoidance pathways Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells Mechanisms and functions of DNA mismatch repair Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium MutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesis Isolated short CTG/CAG DNA slip-outs are repaired efficiently by hMutSbeta, but clustered slip-outs are poorly repaired.Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.Schizosaccharomyces pombe MutSα and MutLα Maintain Stability of Tetra-Nucleotide Repeats and Msh3 of Hepta-Nucleotide Repeats.Short-patch correction of C/C mismatches in human cells.Steady-state regulation of the human DNA mismatch repair system.NEK1 kinase domain structure and its dynamic protein interactome after exposure to Cisplatin.Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase.Mutator phenotypes conferred by MLH1 overexpression and by heterozygosity for mlh1 mutations.Genetic analysis of mouse embryonic stem cells bearing Msh3 and Msh2 single and compound mutations Inactivation of DNA mismatch repair by increased expression of yeast MLH1.Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo.Mismatch repair in correction of replication errors and processing of DNA damage.MSH3-deficiency initiates EMAST without oncogenic transformation of human colon epithelial cells.Control of GT repeat stability in Schizosaccharomyces pombe by mismatch repair factors Functional analysis of human MutSalpha and MutSbeta complexes in yeast Different roles of eukaryotic MutS and MutL complexes in repair of small insertion and deletion loops in yeast.Fusion tyrosine kinase NPM-ALK Deregulates MSH2 and suppresses DNA mismatch repair function novel insights into a potent oncoprotein DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication Large expansion of CTG•CAG repeats is exacerbated by MutSβ in human cells.Interplay between mismatch repair and chromatin assembly Role of mismatch repair enzymes in GAA·TTC triplet-repeat expansion in Friedreich ataxia induced pluripotent stem cells.Tolerance of human MSH2+/- lymphoblastoid cells to the methylating agent temozolomide.Mapping of a functional recombination motif that defines isotype specificity for mu-->gamma3 switch recombination implicates NF-kappaB p50 as the isotype-specific switching factor Somatic expansion in mouse and human carriers of fragile X premutation alleles.Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.

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P2860

Mismatch repair deficiency associated with overexpression of the MSH3 gene

http://www.wikidata.org/entity/Q24681589

description

1998 nî lūn-bûn

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1998 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

1998 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

1998年の論文

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1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

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1998年論文

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1998年论文

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name

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@ast

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@en

Mismatch repair deficiency associated with overexpression of the MSH3 gene

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type

label

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@ast

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@en

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@nl

prefLabel

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@ast

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@en

Mismatch repair deficiency associated with overexpression of the MSH3 gene

@nl

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Proceedings of the National Academy of Sciences of the United States of America

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Mismatch repair deficiency associated with overexpression of the MSH3 gene

@en

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G Marra

http://www.w3.org/2001/XMLSchema#string

G Roscilli

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J Jiricny

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P Delmastro

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T Lettieri

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P2860

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene

Isolation of an hMSH2-p160 heterodimer that restores DNA mismatch repair to tumor cells

GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells

Mutations of GTBP in genetically unstable cells

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

Stimulation of methotrexate resistance and dihydrofolate reductase gene amplification by c-myc

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8568-8573

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15

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Ingram Iaccarino

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