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N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux

N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux

http://www.wikidata.org/entity/Q24800348

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Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT Mechanisms of dopamine transporter regulation in normal and disease states How addictive drugs disrupt presynaptic dopamine neurotransmission Studies of the biogenic amine transporters. 13. Identification of "agonist" and "antagonist" allosteric modulators of amphetamine-induced dopamine release Trace Amines and the Trace Amine-Associated Receptor 1: Pharmacology, Neurochemistry, and Clinical Implications Behavioral, biological, and chemical perspectives on atypical agents targeting the dopamine transporter Spontaneous inward opening of the dopamine transporter is triggered by PIP2-regulated dynamics of the N-terminus Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux.Recognition of psychostimulants, antidepressants, and other inhibitors of synaptic neurotransmitter uptake by the plasma membrane monoamine transporters Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin The rare DAT coding variant Val559 perturbs DA neuron function, changes behavior, and alters in vivo responses to psychostimulants.The role of cannabinoid 1 receptor expressing interneurons in behavior.Effects of brain-derived neurotrophic factor on dopaminergic function and motor behavior during aging Discriminative stimulus effects of cocaine and amphetamine in rats following developmental exposure to polychlorinated biphenyls (PCBs).Locomotor hyperactivity in 14-3-3ζ KO mice is associated with dopamine transporter dysfunction.De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder An N-terminal threonine mutation produces an efflux-favorable, sodium-primed conformation of the human dopamine transporter PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein.The N terminus of monoamine transporters is a lever required for the action of amphetamines Amphetamine induces dopamine efflux through a dopamine transporter channel.Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.Rapid substrate-induced down-regulation in function and surface localization of dopamine transporters: rat dorsal striatum versus nucleus accumbens.Syntaxin 1A regulates dopamine transporter activity, phosphorylation and surface expression.Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters.Effects of amphetamine on subcellular distribution of dopamine and DOPAC.Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder.Salvinorin A regulates dopamine transporter function via a kappa opioid receptor and ERK1/2-dependent mechanism.PKC phosphorylates residues in the N-terminal of the DA transporter to regulate amphetamine-induced DA efflux Regulation of monoamine transporters: Role of transporter phosphorylation.SLC6 transporters: structure, function, regulation, disease association and therapeutics Computational modeling of the N-terminus of the human dopamine transporter and its interaction with PIP2 -containing membranes.Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease.Drosophila melanogaster as a genetic model system to study neurotransmitter transporters.Effect of environmental enrichment on methylphenidate-induced locomotion and dopamine transporter dynamics.Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.N-terminal tagging of the dopamine transporter impairs protein expression and trafficking in vivo.SLC6A3 coding variant Ala559Val found in two autism probands alters dopamine transporter function and trafficking.PKCβ-dependent phosphorylation of the glycine transporter 1.

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P2860

N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux

http://www.wikidata.org/entity/Q24800348

description

2004 nî lūn-bûn

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2004 թուականի Մարտին հրատարակուած գիտական յօդուած

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2004 թվականի մարտին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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N-terminal phosphorylation of ...... for amphetamine-induced efflux

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N-terminal phosphorylation of ...... for amphetamine-induced efflux

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N-terminal phosphorylation of ...... for amphetamine-induced efflux

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N-terminal phosphorylation of ...... for amphetamine-induced efflux

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N-terminal phosphorylation of ...... for amphetamine-induced efflux

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JOURNAL.PBIO.0020078

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N-terminal phosphorylation of ...... for amphetamine-induced efflux

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Aurelio Galli

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Bipasha Guptaroy

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David Lund

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Habibeh Khoshbouei

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Jonathan A Javitch

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L 'Aurelle Johnson

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Margaret E Gnegy

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Namita Sen

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P2860

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter

Macrophage scavenger receptor confers an adherent phenotype to cells in culture

Protein tyrosine kinase inhibitors alter human dopamine transporter activity in Xenopus oocytes.

Familial orthostatic tachycardia due to norepinephrine transporter deficiency.

Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment.

Intracellular patch electrochemistry: regulation of cytosolic catecholamines in chromaffin cells.

Mitogen-activated protein kinase regulates dopamine transporter surface expression and dopamine transport capacity.

Multiple ionic conductances of the human dopamine transporter: the actions of dopamine and psychostimulants.

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2471328

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10.1371/JOURNAL.PBIO.0020078

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15024426

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phosphorylation

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368172

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