The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells. - Wikidata - wikimedia - TriplyDB

The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.

The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.

http://www.wikidata.org/entity/Q24800464

about

Specific small molecule inhibitors of Skp2-mediated p27 degradation Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2 Skp2: a novel potential therapeutic target for prostate cancer Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer B.E.A.R. GeneInfo: a tool for identifying gene-related biomedical publications through user modifiable queries BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells Androgen receptor functions in prostate cancer development and progression Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation.Androgen suppresses the proliferation of androgen receptor-positive castration-resistant prostate cancer cells via inhibition of Cdk2, CyclinA, and Skp2.Androgens as therapy for androgen receptor-positive castration-resistant prostate cancer.Androgens repress expression of the F-box protein Skp2 via p107 dependent and independent mechanisms in LNCaP prostate cancer cells.Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1.AKT3 promotes prostate cancer proliferation cells through regulation of Akt, B-Raf, and TSC1/TSC2.The E3 ubiquitin ligase skp2 regulates neural differentiation independent from the cell cycle.Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation.The role of thyroid hormone in testicular development and function.Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2.The AR dependent cell cycle: mechanisms and cancer relevance.S-phase kinase-associated protein 2 promotes cell growth and motility in osteosarcoma cells.LXR activation causes G1/S arrest through inhibiting SKP2 expression in MIN6 pancreatic beta cells.Recent advances in SCF ubiquitin ligase complex: Clinical implications An AR-Skp2 pathway for proliferation of androgen-dependent prostate-cancer cells.Skp2 regulates non-small cell lung cancer cell growth by Meg3 and miR-3163.Androgens repress Bcl-2 expression via activation of the retinoblastoma (RB) protein in prostate cancer cells.SKP2 associates with p130 and accelerates p130 ubiquitylation and degradation in human cells.The Rho family member RhoE interacts with Skp2 and is degraded at the proteasome during cell cycle progression.EB1089 induces Skp2-dependent p27 accumulation, leading to cell growth inhibition and cell cycle G1 phase arrest in human hepatoma cells.Supraphysiologic Testosterone Therapy in the Treatment of Prostate Cancer: Models, Mechanisms and Questions.CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability.Global analysis of differentially expressed genes in androgen-independent prostate cancer.Chronic β-adrenergic stimulation increases ErbB receptors and cell proliferation in mouse kidney.

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The F-box protein SKP2 mediates androgen control of p27 stability in LNCaP human prostate cancer cells.

http://www.wikidata.org/entity/Q24800464

description

2002 nî lūn-bûn

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2002 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2002 թվականի օգոստոսին հրատարակված գիտական հոդված

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2002年の論文

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Dieter A Wolf

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Holger Schulz

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Lifang Lu

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P2860

Androgen-induced proliferative quiescence in prostate cancer cells: the role of AS3 as its mediator

p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase

The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch

A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits

Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway

Role of the F-box protein Skp2 in lymphomagenesis

Role of the F-box protein Skp2 in adhesion-dependent cell cycle progression

The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p

The ubiquitin system

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and related to the COP9-signalosome and eIF3.

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