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The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

http://www.wikidata.org/entity/Q24802322

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Effects of milk fermented by Lactobacillus helveticus R389 on a murine breast cancer model.The Regulation of Steroid Action by Sulfation and Desulfation Obesity and cancer: at the crossroads of cellular metabolism and proliferation The association between type 2 diabetes mellitus and women cancer: the epidemiological evidences and putative mechanisms Metabolic syndrome and breast cancer risk: a case-cohort study nested in a multicentre italian cohort Inhibiting interleukin-19 activity ameliorates esophageal squamous cell carcinoma progression Exploring estrogenic activity in lung cancer Estrogens and Their Genotoxic Metabolites Are Increased in Obese Prepubertal Girls The clinical significance of PR, ER, NF- κ B, and TNF- α in breast cancer Metabolic syndrome and postmenopausal breast cancer in the ORDET cohort: a nested case-control study The effect of exercise training on the level of tissue IL-6 and vascular endothelial growth factor in breast cancer bearing mice Leptin is overexpressed in the tumor microenvironment of obese patients with estrogen receptor positive breast cancer.The relation of leptin and adiponectin with breast density among premenopausal women.Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status Immune therapy for breast cancer in 2010-hype or hope?n-3 polyunsaturated fatty acids and mechanisms to mitigate inflammatory paracrine signaling in obesity-associated breast cancer.The application of probiotics in cancer.Reciprocal interactions between breast tumor and its adipose microenvironment based on a 3D adipose equivalent model Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland.Variation in inflammatory cytokine/growth-factor genes and mammographic density in premenopausal women aged 50-55.A prospective study of inflammation markers and endometrial cancer risk in postmenopausal hormone nonusers.Neuroinflammation induces glial aromatase expression in the uninjured songbird brain Genetic variation in proinflammatory cytokines IL6, IL6R, TNF-region, and TNFRSF1A and risk of breast cancer.Novel perspective: focusing on the X chromosome in reproductive cancers.Plasma C-reactive protein and risk of breast cancer in two prospective studies and a meta-analysis.Paracrine and endocrine effects of adipose tissue on cancer development and progression.Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort.Effect of tumour necrosis factor-alpha on estrogen metabolic pathways in breast cancer cells.17beta-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer.Caloric restriction reverses obesity-induced mammary gland inflammation in mice.A nested case control study of plasma ICAM-1, E-selectin and TNF receptor 2 levels, and incident primary open-angle glaucoma.Interleukin-19 in breast cancer Detrimental effects of endogenous oestrogens on primary acute myocardial infarction among postmenopausal women The role of chronic inflammation in obesity-associated cancers.Evaluation of Adipokines, Inflammatory Markers, and Sex Hormones in Simple and Complex Breast Cysts' Fluid Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women.Minireview: Obesity and breast cancer: the estrogen connection.Combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal women Inflammatory factors of the tumor microenvironment induce plasticity in nontransformed breast epithelial cells: EMT, invasion, and collapse of normally organized breast textures Molecular pathways: adipose inflammation as a mediator of obesity-associated cancer.

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The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

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The role of cytokines in regul ...... the etiology of breast cancer

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The role of cytokines in regul ...... the etiology of breast cancer

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Atul Purohit

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Michael J Reed

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P2860

Chronic immune activation and inflammation as the cause of malignancy

Crucial role of cytokines in sex steroid formation in normal and tumoral tissues.

Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis.

Aromatase regulation and breast cancer.

Analysis and characteristics of multiple types of human 17beta-hydroxysteroid dehydrogenase.

Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

Detection of intratumoral aromatase in breast carcinomas. An immunohistochemical study with clinicopathologic correlation

Regulation of murine lymphokine production in vivo. III. The lymphoid tissue microenvironment exerts regulatory influences over T helper cell function.

Estrogen formation in stromal cells of adipose tissue of women: induction by glucocorticosteroids

Tissue-specific and hormonally controlled alternative promoters regulate aromatase cytochrome P450 gene expression in human adipose tissue.

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