Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release - Wikidata - wikimedia - TriplyDB

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

http://www.wikidata.org/entity/Q26269912

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Structure and Ca²⁺-binding properties of the tandem C₂ domains of E-Syt2 Dynamic binding mode of a Synaptotagmin-1-SNARE complex in solution Synaptotagmin-1 and -7 Are Redundantly Essential for Maintaining the Capacity of the Readily-Releasable Pool of Synaptic Vesicles Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release Neurotransmitter release: the last millisecond in the life of a synaptic vesicle Inositol hexakisphosphate suppresses excitatory neurotransmission via synaptotagmin-1 C2B domain in the hippocampal neuron Calcium control of neurotransmitter release Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism Push-and-pull regulation of the fusion pore by synaptotagmin-7 Cell biology of Ca2+-triggered exocytosis Activity-dependent IGF-1 exocytosis is controlled by the Ca(2+)-sensor synaptotagmin-10 RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction Molecular Machines Regulating the Release Probability of Synaptic Vesicles at the Active Zone Defining the interaction of perforin with calcium and the phospholipid membrane Synaptotagmin IV determines the linear Ca2+ dependence of vesicle fusion at auditory ribbon synapses.Functional assembly of mammalian cochlear hair cells Calcium regulates molecular interactions of otoferlin with soluble NSF attachment protein receptor (SNARE) proteins required for hair cell exocytosis.Interaction of synaptotagmin with lipid bilayers, analyzed by single-molecule force spectroscopy.Gene expression profiling in the pituitary gland of laying period and ceased period huoyan geese.Differential regulation of synchronous versus asynchronous neurotransmitter release by the C2 domains of synaptotagmin 1.Molecular cloning and expression analysis of the synaptotagmin-1 gene in the hypothalamus and pituitary of Huoyan goose during different stages of the egg-laying cycle Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair.Proton-sensing Ca2+ binding domains regulate the cardiac Na+/Ca2+ exchanger.Post-translational modifications and lipid binding profile of insect cell-expressed full-length mammalian synaptotagmin 1 Molecular underpinnings of synaptic vesicle pool heterogeneity.Reconstituting Intracellular Vesicle Fusion Reactions: The Essential Role of Macromolecular Crowding Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission.NMR characterization of copper and lipid interactions of the C2B domain of synaptotagmin I-relevance to the non-classical secretion of the human acidic fibroblast growth factor (hFGF-1).Synaptotagmin-1 C2B domain interacts simultaneously with SNAREs and membranes to promote membrane fusion.Genetic analysis of synaptotagmin C2 domain specificity in regulating spontaneous and evoked neurotransmitter release.Analysis of SNARE complex/synaptotagmin-1 interactions by one-dimensional NMR spectroscopy.Mutations that disrupt Ca²⁺-binding activity endow Doc2β with novel functional properties during synaptic transmission.Exocytosis and synaptic vesicle function.The molecular machinery of neurotransmitter release (Nobel lecture).Translating neuronal activity at the synapse: presynaptic calcium sensors in short-term plasticity.Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7 C2-domain containing calcium sensors in neuroendocrine secretion.Ferlins Show Tissue-Specific Expression and Segregate as Plasma Membrane/Late Endosomal or Trans-Golgi/Recycling Ferlins.A synaptotagmin suppressor screen indicates SNARE binding controls the timing and Ca2+ cooperativity of vesicle fusion.Triggered Ca2+ influx is required for extended synaptotagmin 1-induced ER-plasma membrane tethering.

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Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release

http://www.wikidata.org/entity/Q26269912

description

2009 nî lūn-bûn

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2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Differential but convergent fu ...... diate neurotransmitter release

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Differential but convergent fu ...... diate neurotransmitter release

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Differential but convergent fu ...... diate neurotransmitter release

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type

label

Differential but convergent fu ...... diate neurotransmitter release

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Differential but convergent fu ...... diate neurotransmitter release

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Differential but convergent fu ...... diate neurotransmitter release

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Differential but convergent fu ...... diate neurotransmitter release

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Differential but convergent fu ...... diate neurotransmitter release

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Differential but convergent fu ...... diate neurotransmitter release

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Proceedings of the National Academy of Sciences of the United States of America

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Differential but convergent fu ...... diate neurotransmitter release

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Jun Xu

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Ok-Ho Shin

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P2860

Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins

Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions

Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release

Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas

Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells

Examining synaptotagmin 1 function in dense core vesicle exocytosis under direct control of Ca2+

Ca2+ binding to synaptotagmin: how many Ca2+ ions bind to the tip of a C2-domain?

Augmenting neurotransmitter release by enhancing the apparent Ca2+ affinity of synaptotagmin 1

Three-dimensional structure of the synaptotagmin 1 C2B-domain: synaptotagmin 1 as a phospholipid binding machine

Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold

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38

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Thomas C. Südhof

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neurotransmitter

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