Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

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http://www.wikidata.org/entity/Q26766341
Elevated PRC1 in gastric carcinoma exerts oncogenic function and is targeted by piperlongumine in a p53-dependent manner.Understanding cell cycle and cell death regulation provides novel weapons against human diseases.Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy.Overaccumulation of p53-mediated autophagy protects against betulinic acid-induced apoptotic cell death in colorectal cancer cells.Mutant p53-Nrf2 axis regulates the proteasome machinery in cancerTargeting mutant p53 for cancer therapy.PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial Therapies.Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors.PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.Defining key concepts of intestinal and epithelial cancer biology through the use of mouse models.Piperlongumine and p53-reactivator APR-246 selectively induce cell death in HNSCC by targeting GSTP1.A combination of p53-activating APR-246 and phosphatidylserine-targeting antibody potently inhibits tumor development in hormone-dependent mutant p53-expressing breast cancer xenografts.Targeting the DNA Damage Response in OSCC with TP53 Mutations.New aspects of antiproliferative activity of 4-hydroxybenzyl isothiocyanate, a natural H2S-donor.Mutant p53 tunes the NRF2-dependent antioxidant response to support survival of cancer cells.Genomic profiles of primary and metastatic esophageal adenocarcinoma identified via digital sorting of pure cell populations: results from a case report
P2860

Targeting of Mutant p53 and the Cellular Redox Balance by APR-246 as a Strategy for Efficient Cancer Therapy

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http://www.wikidata.org/entity/Q26766341
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2016 nî lūn-bûn
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2016年の論文
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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Targeting of Mutant p53 and th ...... y for Efficient Cancer Therapy
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P2093
P2860
P304
P31
P3181
P356
P407
P478
P50
P577
P5875
P698
P932