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HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment

HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment

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A Modified P1 Moiety Enhances in vitro Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and in vitro CNS Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413 Targeting the Brain Reservoirs: Toward an HIV Cure Prevalence of HIV Associated Neurocognitive Deficit among HIV Positive People in Ethiopia: A Cross Sectional Study at Ayder Referral Hospital.IFNβ Protects Neurons from Damage in a Murine Model of HIV-1 Associated Brain Injury MicroRNAs upregulated during HIV infection target peroxisome biogenesis factors: Implications for virus biology, disease mechanisms and neuropathology The potential role of vagus-nerve stimulation in the treatment of HIV-associated depression: a review of literature.Early Antiretroviral Therapy Is Associated with Lower HIV DNA Molecular Diversity and Lower Inflammation in Cerebrospinal Fluid but Does Not Prevent the Establishment of Compartmentalized HIV DNA Populations Brain and liver pathology, amyloid deposition, and interferon responses among older HIV-positive patients in the late HAART era.Comparative DNA Methylation Profiling Reveals an Immunoepigenetic Signature of HIV-related Cognitive Impairment.Inhibition of GABAergic Neurotransmission by HIV-1 Tat and Opioid Treatment in the Striatum Involves μ-Opioid Receptors.NMDARs Adapt to Neurotoxic HIV Protein Tat Downstream of a GluN2A-Ubiquitin Ligase Signaling Pathway.HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis.Astrocytes Resist HIV-1 Fusion but Engulf Infected Macrophage Material.Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens.Neuronal Stress and Injury Caused by HIV-1, cART and Drug Abuse: Converging Contributions to HAND.Aging, Health, and Quality of Life for Older People Living With HIV in Sub-Saharan Africa: A Review and Proposed Conceptual Framework.HIV-1 Tat Primes and Activates Microglial NLRP3 Inflammasome-Mediated Neuroinflammation.Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging.Differential Effects of Antiretroviral Drugs on Neurons In Vitro: Roles for Oxidative Stress and Integrated Stress Response.Interactions between integrase inhibitors and human arginase 1.Selective Vulnerability of Striatal D2 versus D1 Dopamine Receptor-Expressing Medium Spiny Neurons in HIV-1 Tat Transgenic Male Mice.Improving combination antiretroviral therapy by targeting HIV-1 gene transcription.Plasma dickkopf-related protein 1, an antagonist of the Wnt pathway, is associated with HIV-associated neurocognitive impairment.Reverse geroscience: how does exposure to early diseases accelerate the age-related decline in health?HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice.Novel AIDS therapies based on gene editing.Genetics of HIV-associated sensory neuropathy and related pain in Africans.Interplay between Autophagy, Exosomes and HIV-1 Associated Neurological Disorders: New Insights for Diagnosis and Therapeutic Applications.Human Immunodeficiency Virus Promotes Mitochondrial Toxicity.Effort and neuropsychological performance in HIV-infected individuals on stable combination antiretroviral therapy.Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation.Motor-related brain abnormalities in HIV-infected patients: a multimodal MRI study.A GluN2B-Selective NMDAR Antagonist Reverses Synapse Loss and Cognitive Impairment Produced by the HIV-1 Protein Tat.Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants.Role of autophagy in HIV infection and pathogenesis.Dopamine Increases CD14+CD16+ Monocyte Transmigration across the Blood Brain Barrier: Implications for Substance Abuse and HIV Neuropathogenesis.Impairments in Component Processes of Executive Function and Episodic Memory in Alcoholism, HIV Infection, and HIV Infection with Alcoholism Comorbidity.An SIV/macaque model targeted to study HIV-associated neurocognitive disorders.GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro.Mechanisms of CNS Viral Seeding by HIV+ CD14+ CD16+ Monocytes: Establishment and Reseeding of Viral Reservoirs Contributing to HIV-Associated Neurocognitive Disorders.

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HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment

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2016 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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Clinical factors related to brain structure in HIV: the CHARTER study

HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors

Effects of nadir CD4 count and duration of human immunodeficiency virus infection on brain volumes in the highly active antiretroviral therapy era

Human immunodeficiency virus type 1 gp120 induces apoptosis in human primary neurons through redox-regulated activation of neutral sphingomyelinase

A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap

Studies of retroviral infection in humanized mice

Role of neuroimaging in HIV-associated neurocognitive disorders

Paving the path to HIV neurotherapy: Predicting SIV CNS disease

Immunoproteasomes: structure, function, and antigen presentation

HIV and aging: effects on the central nervous system

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