about
CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil.Translational Prospects and Challenges in Human Induced Pluripotent Stem Cell Research in Drug DiscoveryNon-stoichiometric inhibition in integrated lead finding - a literature review.Increased platelet mitochondrial respiration after cardiac arrest and resuscitation as a potential peripheral biosignature of cerebral bioenergetic dysfunction.Solution NMR Spectroscopy in Target-Based Drug Discovery.Early Perspective.The Role of Target Binding Kinetics in Drug Discovery.Drug-Target Kinetics in Drug Discovery.Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens.XPO1 target occupancy measurements confirm the selinexor recommended phase 2 dose.Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).Quantifying the relationship between inhibition of VEGFR-2, drug-induced blood pressure elevation and hypertension.Immunoaffinity LC-MS/MS for quantitative determination of a free and total protein target as a target engagement biomarker.Hit Generation in TB Drug Discovery: From Genome to Granuloma.Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.Analytical considerations for quantitative LC-MS strategies for measuring antibody drug-target engagement in tissues.
P2860
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P2860
description
2015 nî lūn-bûn
@nan
2015 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի մարտին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Target engagement in lead generation
@ast
Target engagement in lead generation
@en
Target engagement in lead generation
@nl
type
label
Target engagement in lead generation
@ast
Target engagement in lead generation
@en
Target engagement in lead generation
@nl
prefLabel
Target engagement in lead generation
@ast
Target engagement in lead generation
@en
Target engagement in lead generation
@nl
P3181
P1476
Target engagement in lead generation
@en
P2093
Timothy B Durham
P304
P3181
P356
10.1016/J.BMCL.2014.12.076
P407
P577
2015-01-12T00:00:00Z