Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells
about
The Impact of Non-Enzymatic Reactions and Enzyme Promiscuity on Cellular Metabolism during (Oxidative) Stress ConditionsMutations induced by 8-hydroxyguanine (8-oxo-7,8-dihydroguanine), a representative oxidized base, in mammalian cellsCrystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survivalHuman mitochondrial transcriptional factor A breaks the mitochondria-mediated vicious cycle in Alzheimer's disease.Expression and function of MutT homolog 1 in distinct subtypes of breast cancer.Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in miceStructural and Kinetic Studies of the Human Nudix Hydrolase MTH1 Reveal the Mechanism for Its Broad Substrate Specificity.Echinacoside Induces Apoptosis in Human SW480 Colorectal Cancer Cells by Induction of Oxidative DNA Damages.Echinacoside induces apoptotic cancer cell death by inhibiting the nucleotide pool sanitizing enzyme MTH1.8-Oxoguanine accumulation in mitochondrial DNA causes mitochondrial dysfunction and impairs neuritogenesis in cultured adult mouse cortical neurons under oxidative conditions.Birth of MTH1 as a therapeutic target for glioblastoma: MTH1 is indispensable for gliomatumorigenesisPrognostic impact of MutT homolog-1 expression on esophageal squamous cell carcinoma.8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle.Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer CellsSpectroscopic evidences of toxic trans-crotonaldehyde trapped and transformed by resveratrol to prevent the damage of mitochondrial DNA.Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable LiabilityRepair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.MUTYH promotes oxidative microglial activation and inherited retinal degeneration.Influences of ethanol on the structure of toxic trans-crotonaldehyde in mitochondria coming from rat myocardium.HIV/HAART-associated oxidative stress is detectable by metabonomics.Chenodeoxycholic Acid Derivative HS-1200 Inhibits Hepatocarcinogenesis and Improves Liver Function in Diethylnitrosamine-Exposed Rats by Downregulating MTH1.Autoantibody biomarkers for the detection of serous ovarian cancer.Downregulation of DNA repair proteins and increased DNA damage in hypoxic colon cancer cells is a therapeutically exploitable vulnerability.The m6A methylation perturbs the Hoogsteen pairing-guided incorporation of an oxidized nucleotide.An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity.Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase (OGG1).In silico prediction of new inhibitors for the nucleotide pool sanitizing enzyme, MTH1, using drug repurposing.MTH1 deficiency selectively increases non-cytotoxic oxidative DNA damage in lung cancer cells: more bad news than good?β-apo-10'-carotenoids support normal embryonic development during vitamin A deficiency.MutT homolog 1 counteracts the effect of anti-neoplastic treatments in adult and pediatric glioblastoma cells.Overexpression of MTH1 and OGG1 proteins in ulcerative colitis-associated carcinogenesis.
P2860
Q26785889-3CD1EECF-A243-4555-8DAC-65B371AF5107Q28073345-DCCB4FE0-02ED-46DD-A89B-0004D495652DQ28115448-DBF41E4A-62E8-42C0-B65F-6735A825361DQ28833673-44F52B4E-F180-4910-8796-634950E32642Q30830038-405F9944-6F39-42FD-B66E-04C28660CCB8Q33598769-3A6C30CC-F238-4FAB-B977-4FD8BB423863Q33799452-DE655E2D-A727-4BF4-9370-7F0B2C6F877CQ34548293-B56A2E75-E4BD-4F46-A222-13D93B2EDA58Q35902424-225B3D92-B71B-4844-A1A0-0BEF5603185BQ36368301-96649EE9-4A7B-4A35-9E6C-9E5373B321E4Q36616050-1DEAF8C4-93A1-4583-8106-AD626EF43D00Q37060804-145AF25A-1AB6-4B29-A602-34D25AD6887AQ37609244-AC997A67-A58C-43CF-87FD-045E1FF1660AQ38670011-BE72B33D-61B1-4417-8934-A2799CB52198Q38777392-4C1E8E57-4D8D-4652-8522-22539FDDC4CFQ38832025-A10139AB-BD83-4BF0-95BE-68038FB2F446Q38943129-B1253FF1-7705-4E3B-B225-B768CC1AB35EQ39087831-098B42A6-C673-4D1A-836D-B58B9003B313Q41159531-51CE269B-E519-4C27-80C6-1004692EE9E6Q41565724-C4816EDE-3896-4EAE-B2E6-7A9D66C2AF08Q41935715-E688CFE1-C539-4C2A-8C73-643D9817A3A7Q42177873-F38AF9CF-6B8B-4134-91C9-4FD7E04F0C8CQ45057481-E95B960B-9E5E-46A5-A752-501CC8C95936Q45804371-63D5C69A-3B2F-4ABA-8A8E-38646BB3109EQ47124942-F3C26EB7-4600-4F59-9EBC-F9EDF18B1C64Q47208435-643BEE93-0AA1-4735-81CB-EEA4CE5D935CQ47803276-7D2BC65E-294A-4024-B7B0-36E81ACAAC64Q53106819-9A32B806-6B63-4AFF-84AD-916304A3D4C6Q55258328-F2D18ACE-7EB9-48C0-BBCE-44C20A760C0FQ55342253-962409AC-8563-479B-8501-226704D9880AQ55398218-38DD30D8-18C5-473E-8C49-B22CC93BA1B5Q55716642-E58F41C9-89FF-48EB-B470-F8BD2D0C8506
P2860
Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells
description
2014 nî lūn-bûn
@nan
2014 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@ast
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@en
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@nl
type
label
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@ast
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@en
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@nl
prefLabel
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@ast
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@en
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@nl
P2860
P921
P3181
P356
P1476
Cellular levels of 8-oxoguanin ...... s and survival of cancer cells
@en
P2093
Yusaku Nakabeppu
P2860
P304
12543-12557
P3181
P356
10.3390/IJMS150712543
P407
P577
2014-07-15T00:00:00Z