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A rat model system to study complex disease risks, fitness, aging, and longevity

A rat model system to study complex disease risks, fitness, aging, and longevity

http://www.wikidata.org/entity/Q26992076

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Genetic analysis of a rat model of aerobic capacity and metabolic fitness Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats Striatal enkephalinergic differences in rats selectively bred for intrinsic running capacity.Eating habits modulate short term memory and epigenetical regulation of brain derived neurotrophic factor in hippocampus of low- and high running capacity rats.Brain diabetic neurodegeneration segregates with low intrinsic aerobic capacity O-GlcNAcylation, contractile protein modifications and calcium affinity in skeletal muscle.Physically active rats lose more weight during calorie restriction.Role of intrinsic aerobic capacity and ventilator-induced diaphragm dysfunction.Exercise Increases Markers of Spermatogenesis in Rats Selectively Bred for Low Running Capacity.High intrinsic aerobic capacity and pomegranate juice are protective against macrophage atherogenecity: studies in high- vs. low-capacity runner (HCR vs. LCR) rats Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms.Contribution of regional brain melanocortin receptor subtypes to elevated activity energy expenditure in lean, active rats Physical activity in adulthood: genes and mortality Enhanced cardiac protein glycosylation (O-GlcNAc) of selected mitochondrial proteins in rats artificially selected for low running capacity.Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome.Phenotypic and molecular differences between rats selectively bred to voluntarily run high vs. low nightly distances.(-)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity.Rapamycin increases grip strength and attenuates age-related decline in maximal running distance in old low capacity runner rats.Selectively bred rat model system for low and high response to exercise training.Leanness and heightened nonresting energy expenditure: role of skeletal muscle activity thermogenesis.Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome Humanized animal exercise model for clinical implication.Uncovering the exercise-related proteome signature in skeletal muscle.Voluntary Running Attenuates Metabolic Dysfunction in Ovariectomized Low-Fit Rats.Selection-, age-, and exercise-dependence of skeletal muscle gene expression patterns in a rat model of metabolic fitness.DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging.Effects of activity, genetic selection and their interaction on muscle metabolic capacities and organ masses in mice.Swimming Training Improves Myocardial Mechanics, Prevents Fibrosis, and Alters Expression of Ca2+ Handling Proteins in Older Rats.Voluntary wheel running improves adipose tissue immunometabolism in ovariectomized low-fit rats.Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms.The role of DNA-PK in aging and energy metabolism.Region-specific differences in bioenergetic proteins and protein response to acute high fat diet in brains of low and high capacity runner rats.Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity.Theoretical and Biological Evaluation of the Link between Low Exercise Capacity and Disease Risk.Intrinsic (Genetic) Aerobic Fitness Impacts Susceptibility for Metabolic Disease.

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A rat model system to study complex disease risks, fitness, aging, and longevity

http://www.wikidata.org/entity/Q26992076

description

2012 nî lūn-bûn

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2012 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2012年の論文

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A rat model system to study complex disease risks, fitness, aging, and longevity

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A rat model system to study complex disease risks, fitness, aging, and longevity

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A rat model system to study complex disease risks, fitness, aging, and longevity

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J.TCM.2012.06.007

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Trends in Cardiovascular Medicine

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A rat model system to study complex disease risks, fitness, aging, and longevity

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Lauren Gerard Koch

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Steven L. Britton

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Ulrik Wisløff

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P2860

Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan

Aerobic metabolism underlies complexity and capacity

Coupling of phosphorylation to electron and hydrogen transfer by a chemi-osmotic type of mechanism

Understanding the odd science of aging

The mitochondrial origin of postischemic arrhythmias.

Artificial selection for intrinsic aerobic endurance running capacity in rats.

Spontaneous activity, economy of activity, and resistance to diet-induced obesity in rats bred for high intrinsic aerobic capacity.

Caloric restriction reverses hepatic insulin resistance and steatosis in rats with low aerobic capacity.

Disrupted sleep and delayed recovery from chronic peripheral neuropathy are distinct phenotypes in a rat model of metabolic syndrome.

Gene expression centroids that link with low intrinsic aerobic exercise capacity and complex disease risk

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