Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor
about
Emergent systems energy laws for predicting myosin ensemble processivityEnergy landscapes reveal the myopathic effects of tropomyosin mutations.Recent Advances in the Molecular Genetics of Familial Hypertrophic Cardiomyopathy in South Asian DescendantsStudy familial hypertrophic cardiomyopathy using patient-specific induced pluripotent stem cellsThe hypertrophic cardiomyopathy myosin mutation R453C alters ATP binding and hydrolysis of human cardiac β-myosinA composite approach towards a complete model of the myosin rodMultidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation.The Qdot-labeled actin super-resolution motility assay measures low-duty cycle muscle myosin step size.Epigallocatechin-3-Gallate Accelerates Relaxation and Ca2+ Transient Decay and Desensitizes Myofilaments in Healthy and Mybpc3-Targeted Knock-in Cardiomyopathic Mice.Approaching the facts between genetic mutation and clinical practice of hypertrophic cardiomyopathy: A case report with RAF1 770C>T mutant.Isolation of single-base genome-edited human iPS cells without antibiotic selection.β-Myosin heavy chain variant Val606Met causes very mild hypertrophic cardiomyopathy in mice, but exacerbates HCM phenotypes in mice carrying other HCM mutationsCopy number variants and the genetic enigma of congenital heart disease.FHL2 expression and variants in hypertrophic cardiomyopathy.Kinetic characterization of the sole nonmuscle myosin-2 from the model organism Drosophila melanogasterModulating Beta-Cardiac Myosin Function at the Molecular and Tissue Levels.Impact of familial hypertrophic cardiomyopathy-linked mutations in the NH2 terminus of the RLC on β-myosin cross-bridge mechanicsPompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes.Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin.Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function.A Haplotype of Two Novel Polymorphisms in δ-Sarcoglycan Gene Increases Risk of Dilated Cardiomyopathy in Mongoloid PopulationEffects of FSGS-associated mutations on the stability and function of myosin-1 in fission yeast.A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic CardiomyopathyA Failure to Communicate: MYOSIN RESIDUES INVOLVED IN HYPERTROPHIC CARDIOMYOPATHY AFFECT INTER-DOMAIN INTERACTION.In vitro and in vivo single myosin step-sizes in striated muscleMyosin regulatory light chain phosphorylation enhances cardiac β-myosin in vitro motility under load.Size and speed of the working stroke of cardiac myosin in situ.A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in DrosophilaMyosin light chains: Teaching old dogs new tricksMutation that causes hypertrophic cardiomyopathy increases force production in human β-cardiac myosinMolecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function.Coiled-coil response to mechanical force: global stability and local crackingNonlinear cross-bridge elasticity and post-power-stroke events in fast skeletal muscle actomyosin.Insights and Challenges of Multi-Scale Modeling of Sarcomere Mechanics in cTn and Tm DCM Mutants-Genotype to Cellular Phenotype.Hypertrophic and dilated cardiomyopathy: four decades of basic research on muscle lead to potential therapeutic approaches to these devastating genetic diseases.Myofilament dysfunction as an emerging mechanism of volume overload heart failure.The genetic landscape of cardiomyopathy and its role in heart failure.Do cardiac actin mutations lead to altered actomyosin interactions?A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice.Myofilaments: Movers and Rulers of the Sarcomere.
P2860
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P2860
Understanding cardiomyopathy phenotypes based on the functional impact of mutations in the myosin motor
description
2012 nî lūn-bûn
@nan
2012 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
Understanding cardiomyopathy p ...... mutations in the myosin motor
@ast
Understanding cardiomyopathy p ...... mutations in the myosin motor
@en
Understanding cardiomyopathy p ...... mutations in the myosin motor
@nl
type
label
Understanding cardiomyopathy p ...... mutations in the myosin motor
@ast
Understanding cardiomyopathy p ...... mutations in the myosin motor
@en
Understanding cardiomyopathy p ...... mutations in the myosin motor
@nl
prefLabel
Understanding cardiomyopathy p ...... mutations in the myosin motor
@ast
Understanding cardiomyopathy p ...... mutations in the myosin motor
@en
Understanding cardiomyopathy p ...... mutations in the myosin motor
@nl
P2860
P3181
P1433
P1476
Understanding cardiomyopathy p ...... mutations in the myosin motor
@en
P2093
D. M. Warshaw
L. Leinwand
P2860
P304
P3181
P356
10.1161/CIRCRESAHA.110.223842
P407
P577
2012-07-20T00:00:00Z