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The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

http://www.wikidata.org/entity/Q27000356

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The Roles of Microtubule-Based Transport at Presynaptic Nerve Terminals Activity-Dependent Degradation of Synaptic Vesicle Proteins Requires Rab35 and the ESCRT Pathway SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.Brain RNA-Seq Profiling of the Mucopolysaccharidosis Type II Mouse Model.Physiological Function and Characterization of TRPCs in Neurons The emerging roles of microRNAs in the pathogenesis of frontotemporal dementia-amyotrophic lateral sclerosis (FTD-ALS) spectrum disorders Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia.Nuclear cytoplasmic trafficking of proteins is a major response of human fibroblasts to oxidative stress The γ-secretase complex: from structure to function.A systems biology strategy to identify molecular mechanisms of action and protein indicators of traumatic brain injury.Proteomics in neurodegenerative diseases: Methods for obtaining a closer look at the neuronal proteome.Stim and Orai proteins in neuronal Ca(2+) signaling and excitability STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.Cognition and Synaptic-Plasticity Related Changes in Aged Rats Supplemented with 8- and 10-Carbon Medium Chain Triglycerides.The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease Signaling pathways regulating neuron-glia interaction and their implications in Alzheimer's disease.Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1 Inhibiting BACE1 to reverse synaptic dysfunctions in Alzheimer's disease.Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment.Disturbed calcium signaling in spinocerebellar ataxias and Alzheimer's disease.Role of endolysosomes and cholesterol in the pathogenesis of Alzheimer's disease: Insights into why statins might not provide clinical benefit.Restoration of motor defects caused by loss of Drosophila TDP-43 by expression of the voltage-gated calcium channel, Cacophony, in central neurons.Physiological and pathophysiological functions of Swiprosin-1/EFhd2 in the nervous system.Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?Calcium signaling and molecular mechanisms underlying neurodegenerative diseases.Role of BACE1 in Alzheimer's synaptic function.Endoplasmic Reticulum Malfunction in the Nervous System.Can the calcium hypothesis explain synaptic loss in Alzheimer's disease?Perspective on the calcium dyshomeostasis hypothesis in the pathogenesis of selective neuronal degeneration in animal models of Alzheimer's disease.The where, what, and when of membrane protein degradation in neurons.Live Observation of Two Parallel Membrane Degradation Pathways at Axon Terminals.Rab GTPases and Membrane Trafficking in Neurodegeneration.

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The synaptic maintenance problem: membrane recycling, Ca2+ homeostasis and late onset degeneration

http://www.wikidata.org/entity/Q27000356

description

2013 nî lūn-bûn

@nan

2013 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2013 թվականի հուլիսին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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The synaptic maintenance probl ...... is and late onset degeneration

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Creative Commons Attribution 2.0 Generic

P2860

Accumulation of rhodopsin in late endosomes triggers photoreceptor cell degeneration

A synaptic model of memory: long-term potentiation in the hippocampus

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

The prolyl isomerase Pin1 regulates amyloid precursor protein processing and amyloid-beta production

Functional characterization of Rab7 mutant proteins associated with Charcot-Marie-Tooth type 2B disease

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.

Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brain

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