Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
about
K-Ras protein as a drug targetKRAS as a Therapeutic TargetRAS Synthetic Lethal Screens Revisited: Still Seeking the Elusive Prize?pMD-Membrane: A Method for Ligand Binding Site Identification in Membrane-Bound ProteinsLipoprotein-biomimetic nanostructure enables efficient targeting delivery of siRNA to Ras-activated glioblastoma cells via macropinocytosis.Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motionsTreatment of NRAS-mutated advanced or metastatic melanoma: rationale, current trials and evidence to dateMapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm.KRAS mutant lung cancer: progress thus far on an elusive therapeutic target.Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC.Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?Metabolic Dependencies in RAS-Driven Cancers.Direct Modulation of Small GTPase Activity and Function.The greedy nature of mutant RAS: a boon for drug discovery targeting cancer metabolism?The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects.K-Ras4B/calmodulin/PI3Kα: A promising new adenocarcinoma-specific drug target?The renewed battle against RAS-mutant cancers.Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants.Calmodulin and PI3K Signaling in KRAS Cancers.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Intrahepatic cholangiocarcinoma: current management and emerging therapies.Independent and core pathways in oncogenic KRAS signaling.Ras: structural details to guide direct targeting.TCL/RhoJ Plasma Membrane Localization and Nucleotide Exchange Is Coordinately Regulated by Amino Acids within the N Terminus and a Distal Loop Region.Genetic status of KRAS influences Transforming Growth Factor-beta (TGF-β) signaling: An insight into Neuropilin-1 (NRP1) mediated tumorigenesis.Strengths and Weaknesses of Pre-Clinical Models for Human Melanoma Treatment: Dawn of Dogs' Revolution for Immunotherapy.Interaction between Wnt/β-catenin and RAS-ERK pathways and an anti-cancer strategy via degradations of β-catenin and RAS by targeting the Wnt/β-catenin pathway.Mechanistic Insights into the Differential Catalysis by RheB and Its Mutants: Y35A and Y35A-D65A.MEK inhibitors for the treatment of NRAS mutant melanoma
P2860
Q26766684-CD8884BF-626A-434B-84E0-BE0946E70C8BQ27007866-18293224-FA63-48DC-A90D-C0001CA071B1Q28260541-91592BE7-1B11-4BF7-9112-D915452C76D6Q28550500-E93A167E-876F-4F6F-81A8-BEA643BE3B7BQ30851435-48428799-5AB2-4107-8C8E-7E54BE82C714Q31142381-9A177108-5873-4726-A7D6-CF9BC35FB8C7Q33887664-732DD890-79C7-42B8-84E9-1DFF25EDE249Q35760976-3833536D-2E3F-4B5E-94F9-90CED039FB08Q36369197-A7920E50-1604-4EC9-A501-53E7F6976CC2Q37673912-05DF7997-27E7-420C-A07F-24683F6C2F95Q38423044-AC9955C0-FD38-4CC6-856C-FA4352AA1710Q38423050-6ADBA878-0ED7-478C-B1E3-B045962EE0B4Q38608107-D2228625-5707-44DD-ABAC-D89D681FFC95Q38612793-78C7CDD7-6797-4316-8922-5BE2A6A761F1Q38718478-B61E1A6F-DEE6-4F0F-87A1-754BEF96BE18Q38731776-148062CE-2A21-46EA-AD0F-ACAEDC3822CEQ38740000-EE837734-487D-476E-AB97-D74D438D7454Q38789349-69AB7FE9-C01E-4B58-BAFE-6E2BE6129E1CQ38809850-8CC5429D-6159-4A30-AA5F-3B3010D425BDQ38891257-991AAF0C-B571-4184-A10C-3EC51E239EB7Q39186928-8537ABD6-5416-4166-9CDF-B28C00170840Q40968374-3FBD819F-EA34-4162-B99D-0DF5145A66BFQ42348795-7D1E09D5-05F6-47E8-8260-018BF454F2BAQ42733331-CFBBB0ED-FEE6-4CCB-B646-00EDEB5B99DFQ50154920-23CDF849-CF7F-4E86-8EB1-F1252A3D12C4Q52657766-E013AB7F-2141-4827-9D3D-1F62817BBE74Q54976921-A479088E-873C-4B68-B03A-00658290D023Q55253300-1D3F8209-B34B-4B39-9650-4AFE9DA962EFQ56889985-47C38833-4D07-41F1-A77A-4724C49C6CA4
P2860
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
description
2015 nî lūn-bûn
@nan
2015 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2015 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
name
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@ast
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@en
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@nl
type
label
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@ast
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@en
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@nl
prefLabel
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@ast
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@en
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@nl
P3181
P1476
Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
@en
P2093
Carla Mattos
P304
P3181
P356
10.1158/1078-0432.CCR-14-2148
P407
P577
2015-04-01T00:00:00Z