about
Redox Imbalance and Viral Infections in Neurodegenerative DiseasesTDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.Targeting RNA binding proteins involved in neurodegeneration.Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia.PABPN1 suppresses TDP-43 toxicity in ALS disease models.Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain.Mechanisms of disease in frontotemporal lobar degeneration: gain of function versus loss of function effectsTDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice.Genetics of amyotrophic lateral sclerosis: an update.A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.Folding of the RNA recognition motif (RRM) domains of the amyotrophic lateral sclerosis (ALS)-linked protein TDP-43 reveals an intermediate stateTDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain.An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis.Predominance of spliceosomal complex formation over polyadenylation site selection in TDP-43 autoregulation.Mesenchymal stem cell therapy for the treatment of amyotrophic lateral sclerosis: signals for hope?TDP-43-The key to understanding amyotrophic lateral sclerosis.Frontotemporal Lobar Degeneration: Mechanisms and Therapeutic Strategies.Quantification of the Relative Contributions of Loss-of-function and Gain-of-function Mechanisms in TAR DNA-binding Protein 43 (TDP-43) ProteinopathiesPhysiological functions and pathobiology of TDP-43 and FUS/TLS proteins.Interactions between RNA-binding proteins and P32 homologues in trypanosomes and human cells.TDP-43 associates with stalled ribosomes and contributes to cell survival during cellular stress.Reduction of polyglutamine toxicity by TDP-43, FUS and progranulin in Huntington's disease models.Reducing TDP-43 aggregation does not prevent its cytotoxicity.Proteomic mapping of differentially vulnerable pre-synaptic populations identifies regulators of neuronal stability in vivoSynapses in neurodegenerative diseases.Molecular neurodegeneration: basic biology and disease pathways.Structural Rearrangement upon Fragmentation of the Stability Core of the ALS-Linked Protein TDP-43.The RNA-Recognition Motifs of TAR DNA-Binding Protein 43 May Play a Role in the Aberrant Self-Assembly of the Protein
P2860
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P2860
description
2012 nî lūn-bûn
@nan
2012 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2012 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
name
Does a loss of TDP-43 function cause neurodegeneration?
@ast
Does a loss of TDP-43 function cause neurodegeneration?
@en
Does a loss of TDP-43 function cause neurodegeneration?
@nl
type
label
Does a loss of TDP-43 function cause neurodegeneration?
@ast
Does a loss of TDP-43 function cause neurodegeneration?
@en
Does a loss of TDP-43 function cause neurodegeneration?
@nl
prefLabel
Does a loss of TDP-43 function cause neurodegeneration?
@ast
Does a loss of TDP-43 function cause neurodegeneration?
@en
Does a loss of TDP-43 function cause neurodegeneration?
@nl
P2860
P921
P3181
P356
P1476
Does a loss of TDP-43 function cause neurodegeneration?
@en
P2093
Zuo-Shang Xu
P2860
P2888
P3181
P356
10.1186/1750-1326-7-27
P407
P5008
P577
2012-06-14T00:00:00Z
P5875
P6179
1033773555