about
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding siteStructural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor DesignX-ray crystal structure of JNK2 complexed with the p38alpha inhibitor BIRB796: insights into the rational design of DFG-out binding MAP kinase inhibitorsInhibitors that stabilize a closed RAF kinase domain conformation induce dimerizationStructural Analysis of the Binding of Type I, I1/2, and II Inhibitors to Eph Tyrosine Kinases.Corticosteroid insensitive alveolar macrophages from asthma patients; synergistic interaction with a p38 mitogen-activated protein kinase (MAPK) inhibitorIn vitro anti-osteoclastogenic activity of p38 inhibitor doramapimod via inhibiting migration of pre-osteoclasts and NFATc1 activity.Characterization of interactions and pharmacophore development for DFG-out inhibitors to RET tyrosine kinase.
P921
Q27638349-E621443B-8E98-4D9A-A92B-96F28AC98CECQ27653949-A27769B0-F881-4083-BF21-6B27511DAB91Q27663588-FFA6B166-AD78-4819-ABEA-71CABB657E8AQ27678182-95901F9F-8A09-4409-BBFF-354BB3DED3A3Q34926887-77925628-9658-40E4-A702-EE21AA8F667EQ35557420-C1CEE02C-29A2-4BB2-997C-6015956CA944Q38423725-F0F54017-2883-47E5-9AB0-E02E58AC8E30Q38999228-C8A529F0-49D6-4DFA-8182-176FF3E4473A
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
doramapimod
@en
type
label
doramapimod
@en
altLabel
1-(3-(1,1-Dimethylethyl)-1-(4- ...... yl)ethoxy)naphthalen-1-yl)urea
@en
1-(5-Tert-Butyl-2-P-Tolyl-2h-P ...... -Ethoxy)-Naphthalen-1-Yl]-Urea
@en
1-[3-tert-butyl-1-(4-methylphe ...... -ylethoxy)naphthalen-1-yl]urea
@en
BIRB 796
@en
BIRB 796BS
@en
BIRB-796
@en
prefLabel
doramapimod
@en
P638
P592
P661
P662
P665
P683
P1579
P2067
P2275
doramapimod
@en
P231
285983-48-4
P233
CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
P234
1S/C31H37N5O3/c1-22-9-11-23(12 ...... 1H,15-20H2,1-4H3,(H2,32,33,37)
P235
MVCOAUNKQVWQHZ-UHFFFAOYSA-N
P274
C₃₁H₃₇N₅O₃
P3117
DTXSID2048957
P592
CHEMBL103667
P638
P652
HO1A8B3YVV