about
Chk1 inhibition as a novel therapeutic strategy for treating triple-negative breast and ovarian cancers.Combined inhibition of Chk1 and Wee1 as a new therapeutic strategy for mantle cell lymphomaIn vitro and in vivo single-agent efficacy of checkpoint kinase inhibition in acute lymphoblastic leukemiaCharacterization of a mantle cell lymphoma cell line resistant to the Chk1 inhibitor PF-00477736PF-00477736 mediates checkpoint kinase 1 signaling pathway and potentiates docetaxel-induced efficacy in xenografts.Gemcitabine and CHK1 inhibition potentiate EGFR-directed radioimmunotherapy against pancreatic ductal adenocarcinoma.Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line.Synergism between bosutinib (SKI-606) and the Chk1 inhibitor (PF-00477736) in highly imatinib-resistant BCR/ABL⁺ leukemia cells.Keeping checkpoint kinases in line: new selective inhibitors in clinical trials
P921
Q34062570-74B52784-73F6-49A5-9D02-2981FCB828E6Q35550255-4B7ABFE9-E614-4F50-97EF-9B8DB126CCF3Q36255484-0317CF69-892A-49DE-BE80-4B164F086F48Q36545701-80A83456-B59F-48F8-A9A9-1B6359E34E6BQ38449769-D4C94163-07F9-4B51-8F92-7D686F7F91A0Q38994037-2AC5818B-F8AC-4AE2-BB45-BEF27857234AQ39131426-8303C450-B50A-4431-9699-841172B06B51Q40063670-C1388A83-8B7E-4FA2-8F15-D6713A808DECQ94705797-FB60A172-EEA0-4361-8E3C-CF0EA2A3254B
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
PF-477736
@en
type
label
PF-477736
@en
altLabel
PF 477736
@en
PF-00477736
@en
prefLabel
PF-477736
@en
P661
P662
P683
P2017
CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[C@@H](C5CCCCC5)N
P2067
419.206973
P233
CN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)C(C5CCCCC5)N
P234
1S/C22H25N7O2/c1-29-11-13(9-25 ...... ,(H,26,31)(H,28,30)/t19-/m1/s1
P235
YFNWWNRZJGMDBR-LJQANCHMSA-N
P274
C₂₂H₂₅N₇O₂