about
Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonistNeuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in miceCharacterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications.RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesiaRF9 Acts as a KISS1R Agonist In Vivo and In Vitro.Anxiogenic and Stressor Effects of the Hypothalamic Neuropeptide RFRP-3 Are Overcome by the NPFFR Antagonist GJ14.NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents.RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions.Starter feeding altered ruminal epithelial bacterial communities and some key immune-related genes' expression before weaning in lambs.RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents.Neuropeptide FF analog RF9 is not an antagonist of NPFF receptor and decreases food intake in mice after its central and peripheral administration.No Evidence That RFamide-Related Peptide 3 Directly Modulates LH Secretion in the Ewe.Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice.Effects of neuropeptide FF and related peptides on the antinociceptive activities of VD-hemopressin(α) in naive and cannabinoid-tolerant mice.In Vitro Activities of Kissorphin, a Novel Hexapeptide KiSS-1 Derivative, in Neuronal Cells.Kisspeptin antagonist prevents RF9-induced reproductive changes in female rats.RF9 excitation of GnRH neurons is dependent upon Kiss1r in the adult male and female mouse.Acute fasting-induced repression of the hypothalamic-pituitary-gonadal axis is reversed by RF-9 administration in the adult male macaque.RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity.The new kisspeptin derivative - kissorphin (KSO) - attenuates acute hyperlocomotion and sensitization induced by ethanol and morphine in mice.Neuropeptide FF Promotes Recovery of Corneal Nerve Injury Associated With Hyperglycemia.Aminoguanidine hydrazone derivatives as non-peptide NPFF1 receptor antagonists reverse opioid induced hyperalgesia.[RF9, a powerful and selective antagonist of the neuropeptide FF receptors, prevents the development of the tolerance to opioids]Effects of kisspeptin on diabetic rat plateletsGonadotropin inhibitory hormone and RF9 stimulate hypothalamic-pituitary-adrenal axis in adult male rhesus monkeys
P921
Q28268759-19AF0461-C8EB-4A75-824E-0EB4907FF85BQ28276253-22AD64A6-CFD7-4098-910C-9D47AB541F95Q34099107-79C9BB53-F480-4B26-9DD6-1216EF021EAAQ34249621-5FDE42C4-C9DE-40E6-B4FF-74F4CDA78CB1Q36305133-252EFAF8-DA4A-434B-A555-60A34904448EQ38413167-C20E561B-0FA7-4C0D-8BC7-A186A9A79654Q38616292-B713DCBF-6463-4A70-990F-64CC34DB8230Q38741804-3BEA50BE-44A6-4FA0-88E1-236118006949Q38852203-8897158C-CBCB-4037-A263-F7286DA33EC3Q38910578-DC5D9EF1-501A-4018-85C9-9FE7BFAA7BE1Q39216115-82F8C5D7-62E3-4996-AC3F-15BD5E523D45Q40008325-D787F7DE-3E16-4C0D-A622-7D4D4F4C4414Q40340321-A289360C-1132-4726-B920-8738DC271A52Q40426298-2BD0825C-1115-4C43-81CD-14A971DF1B68Q41899860-62BA88A6-D054-4258-9566-5F771249D42EQ47743459-0A20A90A-C5CA-457A-AAC9-5BA1E091F0A9Q48483064-BF419565-2328-4698-9615-8DA8BA55CB79Q48568836-50288C89-1C0E-46C2-85C5-0C343C98EE18Q48689888-E61A63DF-3471-418C-BE04-DA04D228F3A3Q53051089-95757E57-A5F6-42AB-883A-48D5476C0EBAQ53257958-C0EEEC7F-F670-48BA-AC1C-3D64267FF61FQ53681114-E9E086DE-327B-48F9-A3CC-FE941B7F6CBDQ79859600-BED2C3A9-8735-4D73-8B8C-F14E9A893D1AQ88610913-2774014B-4B7C-4B83-B0E2-42D04A80E86AQ88635423-B12D7201-AC88-4C5E-8B18-7BAAA2241FD8
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
RF9
@en
type
label
RF9
@en
altLabel
1-Adamantanecarbonyl-RF-NH2
@en
prefLabel
RF9
@en
P592
P661
P662
P683
P2017
C1C2CC3CC1CC(C2)(C3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N
P2067
482.300539
P233
C1C2CC3CC1CC(C2)(C3)C(=O)NC(CCCN=C(N)N)C(=O)NC(CC4=CC=CC=C4)C(=O)N
P234
1S/C26H38N6O3/c27-22(33)21(12- ...... t17?,18?,19?,20-,21-,26?/m0/s1
P235
UMKHUSRDQFQHAK-RNJMTYCLSA-N
P274
C₂₆H₃₈N₆O₃
P592
CHEMBL1672380