about
Discovery of AZD8931, an Equipotent, Reversible Inhibitor of Signaling by EGFR, HER2, and HER3 Receptors.Therapeutic potential of the dual EGFR/HER2 inhibitor AZD8931 in circumventing endocrine resistance.AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer modelsCombining AZD8931, a novel EGFR/HER2/HER3 signalling inhibitor, with AZD5363 limits AKT inhibitor induced feedback and enhances antitumour efficacy in HER2-amplified breast cancer models.Metabolic disposition of AZD8931, an oral equipotent inhibitor of EGFR, HER2 and HER3 signalling, in rat, dog and man.AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor, ERBB2 (HER2), and ERBB3: a unique agent for simultaneous ERBB receptor blockade in cancer.Inhibition of EGFR, HER2 and HER3 signaling with AZD8931 alone and in combination with paclitaxel: phase i study in Japanese patients with advanced solid malignancies and advanced breast cancer.The first radiosynthesis of [(11)C]AZD8931 as a new potential PET agent for imaging of EGFR, HER2 and HER3 signaling.
P921
Q33635861-F92A27ED-ECCF-4A77-83B0-153D7E03343FQ33648503-DC6D24ED-804E-4ECE-9924-1FC18A74A346Q33770856-22993DC2-7D5C-43CE-929A-685D19144B06Q35849919-4EECBDCE-6C19-4ED1-805D-619BCDB6E1BBQ38427102-DFE1FEC0-4785-45C6-BA90-5C8B04367016Q39741482-8E6094DC-8FC2-4E74-AC98-D3032E290DADQ51137512-5F28B621-4A6D-4593-A223-3D24079A45CEQ54327693-7A81D1B1-B403-4FA5-B7BC-F4CECCFFB266
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
sapitinib
@en
type
label
sapitinib
@en
altLabel
AZD-8931
@en
AZD8931
@en
prefLabel
sapitinib
@en
P592
P661
P662
P683
P2067
473.162996
P231
848942-61-0
P232
P233
CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC
P234
1S/C23H25ClFN5O3/c1-26-21(31)1 ...... H2,1-2H3,(H,26,31)(H,27,28,29)
P235
DFJSJLGUIXFDJP-UHFFFAOYSA-N
P2566
100.170.260
P274
C₂₃H₂₅ClFN₅O₃
P3117
DTXSID50233942
P592
CHEMBL2408045
P652
3499328002