about
P3781
Sapropterin dihydrochloride for phenylketonuriaActivation of phenylalanine hydroxylase induces positive cooperativity toward the natural cofactorNew era in treatment for phenylketonuria: Pharmacologic therapy with sapropterin dihydrochloride.Evolving patient selection and clinical benefit criteria for sapropterin dihydrochloride (Kuvan®) treatment of PKU patients.Introduction of sapropterin dihydrochloride as standard of care in patients with phenylketonuria.Up to date knowledge on different treatment strategies for phenylketonuria.Sapropterin dihydrochloride: a new drug and a new concept in the management of phenylketonuria.Bi-modal dose-dependent cardiac response to tetrahydrobiopterin in pressure-overload induced hypertrophy and heart failureRelative bioavailability of sapropterin from intact and dissolved sapropterin dihydrochloride tablets and the effects of food: a randomized, open-label, crossover study in healthy adults.Pahenu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo.Efficacy and safety of sapropterin dihydrochloride in patients with phenylketonuria: A meta-analysis of randomized controlled trialsSafety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertensionSTART, a double blind, placebo-controlled pharmacogenetic test of responsiveness to sapropterin dihydrochloride in phenylketonuria patientsSafety of extended treatment with sapropterin dihydrochloride in patients with phenylketonuria: results of a phase 3b study
P921
Q24234826-E4C89E76-8149-4D8C-8075-996D513CD1C7Q24293412-4625DFE4-1944-45B4-BC1E-E49CEF21E47BQ34064376-F1615ACE-8EDF-4EA1-98E2-14813C85CC8EQ34252544-42482745-92B1-4C62-A161-D29C65ED2183Q35103204-667119B1-DCBD-44B4-85AF-208C697470A6Q35623929-51E4B769-0EF2-413C-9CA1-6C3E97D25194Q37787066-D3CDB538-5C4F-4051-ADD1-11412E75023CQ40374460-61488F1B-95A1-4391-9D91-CFD0ECFAED0DQ43141107-1F1A9ABE-CC44-4CF7-A01B-CE7E3976D014Q43152626-08D325D4-A4E6-4D5D-9855-66339E03CE41Q64078924-8C652EB4-FCD3-471A-B6D1-47C4D562D43FQ82457097-59764D58-9568-4E5F-B721-D97B9DEBC467Q82658512-34FAB773-B468-4DD8-A2D7-AEE14447F38FQ84286469-0839F10C-E9E5-4019-9B0C-0EB9009DECDE
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
sapropterin dihydrochloride
@en
type
label
sapropterin dihydrochloride
@en
altLabel
(6R)-tetrahydrobiopterin dihydrochloride
@en
(6R)-tetrahydrobiopterin hydrochloride
@en
sapropterin 2HCl
@en
sapropterin hydrochloride
@en
prefLabel
sapropterin dihydrochloride
@en
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C[C@@H]([C@@H]([C@H]1CNC2=C(N1)C(=O)N=C(N2)N)O)O.Cl.Cl
P2067
313.070845
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N0000176129
P231
69056-38-8
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P233
CC(C(C1CNC2=C(N1)C(=O)N=C(N2)N)O)O.Cl.Cl
P234
1S/C9H15N5O3.2ClH/c1-3(15)6(16 ...... 4,17);2*1H/t3-,4+,6-;;/m0../s1
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RKSUYBCOVNCALL-NTVURLEBSA-N
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100.189.958
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C₉H₁₇Cl₂N₅O₃
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DTXSID0040620
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CHEMBL1201775