about
ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citriniumCompetitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity.Single-step production of the simvastatin precursor monacolin J by engineering of an industrial strain of Aspergillus terreus.Biochemical aspect of HMG CoA reductase inhibitors.Comparison of the effect of six compactin-related compounds on cholesterol synthesis in five human cell types.Transformations of cyclic nonaketides by Aspergillus terreus mutants blocked for lovastatin biosynthesis at the lovA and lovC genes.Competitive inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by ML-236A and ML-236B fungal metabolites, having hypocholesterolemic activity. 1976.Inhibition of cholesterol synthesis in vitro and in vivo by ML-236A and ML-236B, competitive inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseMicrobial conversion of compactin (ML-236B) to ML-236A6 alpha-Hydroxy-iso-ML-236B (6 alpha-hydroxy-iso-compactin) and ML-236A, microbial transformation products of ML-236B
P921
Q28140305-39F1FCD1-F709-4CC7-9EC6-8AD07E9CCED5Q34563795-539747D4-0EDD-4E70-86B2-B68547F7D203Q38723555-30F1D5A9-7A48-432B-8322-AA573133D86EQ38768432-1E246194-F490-4387-8924-19DD42D617F3Q41715408-730C65CF-6AAE-49B8-A24B-B9EED4EDE6E9Q44556635-A2B78596-C63A-4FD3-A44B-2B0B97F60753Q45142605-08EC6FBC-DA07-4D02-B6FC-55776E581900Q67685401-A57B147D-1FE3-4EA3-9467-5C044BAAB892Q69693669-AEA06BEF-CA70-4E75-B1BA-EA08472BCB17Q70819178-73A95976-24E9-4064-8D7E-9658FB1A8A3E
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
Compactin diol lactone
@en
type
label
Compactin diol lactone
@en
altLabel
ML-236A
@en
prefLabel
Compactin diol lactone
@en
P661
P662
P665
P683
P2017
C[C@H]1C=CC2=CCC[C@@H]([C@@H]2[C@H]1CC[C@@H]3C[C@H](CC(=O)O3)O)O
P2064
P2067
306.183109
P231
58889-19-3
P233
CC1C=CC2=CCCC(C2C1CCC3CC(CC(=O)O3)O)O
P234
1S/C18H26O4/c1-11-5-6-12-3-2-4 ...... t11-,13+,14+,15-,16-,18-/m0/s1
P235
WWSNTLOVYSRDEL-DZSDEGEFSA-N
P274
P3117
DTXSID20207599