about
Tfap2a promotes specification and maturation of neurons in the inner ear through modulation of Bmp, Fgf and notch signaling.Therapeutic potential of a gamma-secretase inhibitor for hearing restoration in a guinea pig model with noise-induced hearing lossNotch inhibition induces cochlear hair cell regeneration and recovery of hearing after acoustic trauma.Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cellsA multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.Gamma secretase inhibitors of Notch signalingCapture and 3D culture of colonic crypts and colonoids in a microarray platform.Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575.Studies of Abeta pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[Quantitative measurement of changes in amyloid-beta(40) in the rat brain and cerebrospinal fluid following treatment with the gamma-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydropPKCα-mediated effect on in vitro Aβ production in response to gamma secretase inhibitor LY411575 in rat CTXTNA2 astrocytes.
P921
Q30416233-137E546A-F7E6-4820-9D36-A43A9E619676Q30436875-20753703-DEB2-4F14-99AD-D0EFB56023BEQ30444617-26A449DB-F160-41D1-83E5-7F88F7B369C4Q31143812-BAD54298-0644-4C5F-8E72-72AD021DA074Q34231812-F5AC0D84-5AC7-4DD3-904F-397FF5B76BA1Q36562023-89DDC7D0-FCC6-45AD-81B9-1FFD3B7DA253Q37053722-606EAAE9-6611-43FF-9F13-C87377EFEA64Q41790388-CBF92E18-8051-4910-92F4-E4389AD12257Q41989700-5850CB62-05FC-46AA-9AD9-48D9CFDE216BQ44725362-CB550F5E-72BE-4AD3-B01D-CE3C64B49991Q45295786-76AF2076-4F1E-404D-B793-39E609E8B4CEQ50945846-70A9D1A4-8132-4064-9FC2-8FEF8F332997
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
LY-411575
@en
type
label
LY-411575
@en
altLabel
LSN-411575
@en
LY411575
@en
N(2)-[(2S)-2-(3,5-difluorophen ...... b,d]azepin-7-yl]-L-alaninamide
@en
prefLabel
LY-411575
@en
P592
P661
P662
P683
P1579
P2017
C[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O
P2067
P231
209984-57-6
P233
CC(C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)C(C4=CC(=CC(=C4)F)F)O
P234
1S/C26H23F2N3O4/c1-14(29-25(34 ...... 4)(H,30,33)/t14-,22-,23-/m0/s1
P235
ULSSJYNJIZWPSB-CVRXJBIPSA-N
P274
C₂₆H₂₃F₂N₃O₄
P3117
DTXSID40439850
P592
CHEMBL392068