A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma
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Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in CancerEpithelial to Mesenchymal Transition in a Clinical PerspectiveEpithelial-mesenchymal plasticity of breast cancer stem cells: implications for metastasis and therapeutic resistancePushing tumor cells towards a malignant phenotype: stimuli from the microenvironment, intercellular communications and alternative roadsEpithelial-mesenchymal plasticity in carcinoma metastasisTumors of the neural crest: Common themes in development and cancerEpithelial-mesenchymal transition: focus on metastatic cascade, alternative splicing, non-coding RNAs and modulating compoundsThe emerging molecular machinery and therapeutic targets of metastasisA Novel High-Throughput 3D Screening System for EMT Inhibitors: A Pilot Screening Discovered the EMT Inhibitory Activity of CDK2 Inhibitor SU9516Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiationReal-time analysis of epithelial-mesenchymal transition using fluorescent single-domain antibodiesComputer-assisted quantification of motile and invasive capabilities of cancer cells.New insights into the role of EMT in tumor immune escape.Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migration identifies multiple pathways potentially involved in metastatic invasion.Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)Identification of drugs as single agents or in combination to prevent carcinoma dissemination in a microfluidic 3D environmentCombinatorial treatment using targeted MEK and SRC inhibitors synergistically abrogates tumor cell growth and induces mesenchymal-epithelial transition in non-small-cell lung carcinoma.An EMT spectrum defines an anoikis-resistant and spheroidogenic intermediate mesenchymal state that is sensitive to e-cadherin restoration by a src-kinase inhibitor, saracatinib (AZD0530).Superior efficacy of co-treatment with the dual PI3K/mTOR inhibitor BEZ235 and histone deacetylase inhibitor Trichostatin A against NSCLCStrategies to increase drug penetration in solid tumors.Biomechanics of TGFβ-induced epithelial-mesenchymal transition: implications for fibrosis and cancerNovel application of the published kinase inhibitor set to identify therapeutic targets and pathways in triple negative breast cancer subtypes.A sea urchin in vivo model to evaluate Epithelial-Mesenchymal Transition.The development of high-content screening (HCS) technology and its importance to drug discovery.Therapeutic Targeting of Epithelial Plasticity Programs: Focus on the Epithelial-Mesenchymal Transition.Pharmacological and immunological targeting of tumor mesenchymalization.EMT and tumor metastasisThe EMT spectrum and therapeutic opportunities.Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer.Integration of pan-cancer transcriptomics with RPPA proteomics reveals mechanisms of epithelial-mesenchymal transition.The GAS6-AXL signaling network is a mesenchymal (Mes) molecular subtype-specific therapeutic target for ovarian cancer.Cellular Phenotype Plasticity in Cancer Dormancy and Metastasis
P2860
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P2860
A cell-based small molecule screening method for identifying inhibitors of epithelial-mesenchymal transition in carcinoma
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
A cell-based small molecule sc ...... chymal transition in carcinoma
@ast
A cell-based small molecule sc ...... chymal transition in carcinoma
@en
A cell-based small molecule sc ...... chymal transition in carcinoma
@nl
type
label
A cell-based small molecule sc ...... chymal transition in carcinoma
@ast
A cell-based small molecule sc ...... chymal transition in carcinoma
@en
A cell-based small molecule sc ...... chymal transition in carcinoma
@nl
prefLabel
A cell-based small molecule sc ...... chymal transition in carcinoma
@ast
A cell-based small molecule sc ...... chymal transition in carcinoma
@en
A cell-based small molecule sc ...... chymal transition in carcinoma
@nl
P2093
P2860
P3181
P1433
P1476
A cell-based small molecule sc ...... chymal transition in carcinoma
@en
P2093
Boon Cher Goh
Jean Paul Thiery
Shi-Yun Lee
Victor Racine
Wen-Jing Sim
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0033183
P407
P577
2012-03-14T00:00:00Z