GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity
about
Claudins in intestines: Distribution and functional significance in health and diseasesGuanylyl cyclase C signaling axis and colon cancer preventionAntiobesity pharmacotherapy: new drugs and emerging targetsNew advances in models and strategies for developing anti-obesity drugs.Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins.Sildenafil normalizes bowel transit in preclinical models of constipationTranslating colorectal cancer prevention through the guanylyl cyclase C signaling axis.Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune toleranceEffect of guanylate cyclase-C activity on energy and glucose homeostasisGuanylate cyclase C limits systemic dissemination of a murine enteric pathogen.A novel CDX2 isoform regulates alternative splicing.A comparison of linaclotide and lubiprostone dosing regimens on ion transport responses in human colonic mucosaExploring the physiology and pathology of aging in the intestine of Drosophila melanogasterAlpha-Melanocyte Stimulating Hormone Protects against Cytokine-Induced Barrier Damage in Caco-2 Intestinal Epithelial MonolayersPlecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis.The guanylate cyclase-C signaling pathway is down-regulated in inflammatory bowel diseaseIntestinal barrier dysfunction links metabolic and inflammatory markers of aging to death in Drosophila.Rapamycin preserves gut homeostasis during Drosophila aging.GUCY2C: at the intersection of obesity and cancerPharmacology and clinical potential of guanylyl cyclase C agonists in the treatment of ulcerative colitis.Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index.GUCY2C ligand replacement to prevent colorectal cancer.Guanylate cyclase C deficiency causes severe inflammation in a murine model of spontaneous colitisIL-23R+ innate lymphoid cells induce colitis via interleukin-22-dependent mechanism.Type 2 cGMP-dependent protein kinase regulates homeostasis by blocking c-Jun N-terminal kinase in the colon epithelium.Cyclic nucleotide signaling in intestinal epithelia: getting to the gut of the matter.Products for the treatment of inflammatory bowel disease: a patent review (2013 - 2014).cGMP Signaling Increases Antioxidant Gene Expression by Activating Forkhead Box O3A in the Colon Epithelium.Guanylate cyclase C as a target for prevention, detection, and therapy in colorectal cancer.Secretome of Intestinal Bacilli: A Natural Guard against Pathologies.GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome.Obesity-Induced Colorectal Cancer Is Driven by Caloric Silencing of the Guanylin-GUCY2C Paracrine Signaling Axis.GUCY2C maintains intestinal LGR5+ stem cells by opposing ER stress.Cyclic-GMP-Elevating Agents Suppress Polyposis in ApcMin mice by Targeting the Preneoplastic Epithelium.Absence of receptor guanylyl cyclase C enhances ileal damage and reduces cytokine and antimicrobial peptide production during oral Salmonella Typhimurium infection.Sildenafil Suppresses Inflammation-Driven Colorectal Cancer in Mice.Clinical utility of plecanatide in the treatment of chronic idiopathic constipationThe Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia
P2860
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P2860
GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity
description
2012 nî lūn-bûn
@nan
2012 թուականին հրատարակուած գիտական յօդուած
@hyw
2012 թվականին հրատարակված գիտական հոդված
@hy
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
name
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@ast
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@en
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@nl
type
label
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@ast
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@en
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@nl
prefLabel
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@ast
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@en
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@nl
P2093
P2860
P50
P3181
P1433
P1476
GUCY2C opposes systemic genoto ...... t intestinal barrier integrity
@en
P2093
Alex Vladimir Mejia Garcia
Brian Arthur Stoecker
Gilbert Won Kim
Jieru Egeria Lin
Michael Anthony Valentino
Stephanie Schulz
Terry Hyslop
P2860
P304
P3181
P356
10.1371/JOURNAL.PONE.0031686
P407
P577
2012-01-01T00:00:00Z